 | Ross River virus causes an age-dependent and virus strain-dependent destructive infection of striated muscle and connective tissue in limbs and joints and hind limb paralysis in mice. This is not a perfect model of the debilitating arthritis, arthralgia seen in infected humans, but nevertheless there are merits to the model since the pathogenesis of alphavirus-induced arthritic disease in humans is not well understood. Here Ross River virus virions are budding from the plasma membrane of hind limb muscle cells 5 days post infection. Magnification approximately x40,000.
Micrograph from F. A. Murphy, University of Texas Medical Branch, Galveston, Texas.
Micrograph from F. A. Murphy, University of Texas Medical Branch, Galveston, Texas. Download TIF |