PhD, 2000, University of the Pacific (Major/Minor: Biochemistry/Mass Spectrometry)
1998-2000
Predoc. University of California at San Francisco (Major: Mass Spectrometry)
1994-1997
MS, 1997, University of the Pacific (Major/Minor: Biochemistry/NMR)
1987-1990
MS, 1990, East China University of Science & Technology (Major/Minor: Analytical Chemistry /Mass Spectrometry/)
1980-1984
BS, 1984, Anhui University Major/Minor: Chemistry/Analytical Chemistry)
Dr. Zhang was trained at UCSF Mass Spectrometry Facility under the
direction of Dr. Alma Burlingame, the chief editor of the Journal of
Molecular and Cellular Proteomics. His research interest focuses on the
development of state-of-the-art methodologies in mass spectrometry and
their applications in epigenetics, with the hope of better understanding
the cause of diseases and cancer. His current research is the study of
one-carbon metabolism and histone methylation in hypoxic cancer cells
by mass spectrometry and biochemistry.
Zhang K, Williams KE, Huang L, Yau P, Siino JS, Bradbury EM, Jones PR, Minch MJ, Burlingame AL. Histone acetylation and deacetylation: identification of acetylation and methylation sites of HeLa histone H4 by mass spectrometry. Molecular
& cellular proteomics : MCP. 2002; 1(7):500-8. PMID:12239278
Zhang K, Yau PM, Chandrasekhar B, New R, Kondrat R, Imai BS, Bradbury ME.Differentiation between peptides containing acetylated or tri-methylated lysines by mass spectrometry: an application for determining lysine 9 acetylation and
methylation of histone H3. Proteomics. 2004; 4(1):1-10. PMID:14730666
Xu F, Zhang K, Grunstein M. Acetylation in histone H3 globular domain regulates gene expression in yeast. Cell. 2005; 121(3):375-85. PMID:15882620
Sridhar VV, Kapoor A, Zhang K, Zhu J, Zhou T, Hasegawa PM, Bressan RA, Zhu JK. Control of DNA methylation and heterochromatic silencing by histone H2B deubiquitination. Nature. 2007; 447(7145):735-8.PMID: 17554311
Horwitz GA, Zhang K, McBrian MA, Grunstein M, Kurdistani SK, Berk AJ. Adenovirus small e1a alters global patterns of histone modification. Science. 2008; 321(5892):1084-5. PMID:18719283
Liu B, Lin Y, Darwanto A, Song X, Xu G, Zhang K. Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells. The Journal of biological chemistry. 2009; 284(47):32288-95. PMID: 19801601
Darwanto A, Curtis MP, Schrag M, Kirsch W, Liu P, Xu G, Neidigh JW, Zhang K. A modified "cross-talk" between histone H2B Lys-120 ubiquitination and H3 Lys-79 methylation. The Journal of biological chemistry. 2010; 285(28):21868-76.
PMID: 20442396
Tang H, Fang H, Yin E, Brasier AR, Sowers LC, Zhang K. Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometer. Analytical chemistry. 2014; 86(11):5526-34.PMID:24823915
Nicholas D, Tang H, Zhang Q, Rudra J, Xu F, Langridge W, Zhang K. Quantitative proteomics reveals a role for epigenetic reprogramming during human monocyte differentiation. Molecular & cellular proteomics : MCP. 2015; 14(1):15-29.
PMID: 25316709
Sowers JL, Mirfattah B, Xu P, Tang H, Park IY, Walker C, Wu P, Laezza F, Sowers LC, Zhang K. Quantification of histone modifications by parallel-reaction monitoring: a method validation. Analytical chemistry. 2015; 87(19):10006-14.
PMID: 26356480
