Obstetric-Fetal Pharmacology Research Centers

Tacrolimus Placental Transfer at Delivery and Neonatal Exposure through Breast Milk

Zheng, S., Easterling, T. R., Hays, K., Umans, J. G., Miodovnik, M., Clark, S., Calamia, J. C., Thummel, K. E., Shen, D. D., Davis, C. L., Hebert, M. F. (2013). Tacrolimus Placental Transfer at Delivery and Neonatal Exposure through Breast Milk. British Journal of Clinical Pharmacology, 76(6), 988-96. doi: 10.1111/bcp.12122. (PMID: 23528073)

Duration of cisplatin excretion in breast milk

Hays, K. E., Ryu, R. J., Swisher, E. M., Reed, E., McManus, T., Rybeck, B., Petros, W. P., & Hebert, M. F. (2013). Duration of cisplatin excretion in breast milk. Journal of Human Lactation, 29(4), 469-72. doi: 10.1177/0890334413479671. (PMID: 23492761)

Transplacental transfer and distribution of pravastatin

Nanovskaya, T. N., Patrikeeva, S. L., Paul, J., Costantine, M. M., Hankins, G. D., & Ahmed, M. S. (2013). Transplacental transfer and distribution of pravastatin. American Journal of Obstetrics and Gynecology, 209(4), 373.e1-5. doi: 10.1016/j.ajog.2013.05.038. (PMID: 24070396)

Reply: To PMID 23453884

Caritis, S. N., Zhao, Y., Venkataramanan, R., & Bettinger, J. (2013). Reply: To PMID 23453884. American Journal of Obstetrics and Gynecology, 209(3), 285-6. doi: 10.1016/j.ajog.2013.04.038. (PMID: 23643571)

Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography-mass spectrometry

Wang, X., Rytting, E., Abdelrahman, D. R., Nanovskaya, T. N., Hankins, G. D., & Ahmed, S. (2013). Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography-mass spectrometry. Biomedical Chromatography, 27(7), 866-73. doi: 10.1002/bmc.2873. (PMID: 23401067)

A Pharmacologic Approach to the Use of Glyburide in Pregnancy

Caritis, S. N., & Hebert, M. F. (2013). A Pharmacologic Approach to the Use of Glyburide in Pregnancy. Obstetrics and Gynecology, 121(6), 1309-12. doi: 10.1097/AOG.0b013e31829007f0. (PMID: 23812467)

Qualitative and quantitative measures of various compounded formulations of 17-alpha hydroxyprogesterone caproate

Caritis, S. N., Zhao, Y., Bettinger, J., & Venkataramanan, R. (2013). Qualitative and quantitative measures of various compounded formulations of 17-alpha hydroxyprogesterone caproate. American Journal of Obstetrics and Gynecology, 208(6), 470.e1-5. doi: 10.1016/j.ajog.2013.02.028. (PMID: 23453884)

A liquid chromatography method with single quadrupole mass spectrometry for quantitative determination of indomethacin in maternal plasma and urine of pregnant patients

Wang, X., Vernikovskaya, D. I., Nanovskaya, T. N., Rytting, E., Hankins, G. D., & Ahmed, M. S. (2013). A liquid chromatography method with single quadrupole mass spectrometry for quantitative determination of indomethacin in maternal plasma and urine of pregnant patients. Journal of Pharmaceutical and Biomedical Analysis, 78-79, 123-8. doi: 10.1016/j.jpba.2013.02.006. (PMID: 23474812)

Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic

Haas, D. M., Quinney, S. K., Clay, J., Renbarger, J. L., Hebert, M. F., Clark, S., Umans, J., & Caritis, S. N., for the Obstetric-Fetal Pharmacology Research Units Network (2013). Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic. American Journal of Perinatology, 30(4), 275-81. doi: 10.1055/s-0032-1323590. (PMID: 22875663)

Interpreting tacrolimus concentrations during pregnancy and postpartum

Hebert, M. F., Zheng, S., Hays, K., Shen, D. D., Davis, C. L., Umans, J. G., Miodovnik, M., Thummel, K. E., & Easterling, T. R. (2013). Interpreting tacrolimus concentrations during pregnancy and postpartum. Transplantation, 95(7), 908-15. doi: 10.1097/TP.0b013e318278d367. (PMID: 23274970)

A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women

Ke, A. B., Nallani, S. C., Zhao, P., Rostami-Hodjegan, A., Isoherranen, N., & Unadkat, J. D. (2013). A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women. Drug Metabolism and Disposition, 41(4), 801-13. doi: 10.1124/dmd.112.050161. (PMID: 23355638)

The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration

Haas, D. M., Dantzer, J., Lehmann, A. S., Philips, S., Skaar, T. C., McCormick, C. L., Hebbring, S. J., Jung, J., & Li, L. (2013). The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration. American Journal of Obstetrics and Gynecology, 208(3), 215.e1-6. doi: 10.1016/j.ajog.2012.12.031. (PMID: 23295978)

Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy

Matok, I., Clark, S., Caritis, S., Miodovnik, M., Umans, J., Hankins, G., & Koren, G. (2013). Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy. Journal of Clinical Pharmacology, 53(3), 334-8. doi: 10.1177/0091270012445207. (PMID: 23444286)

Pravastatin for the prevention of preeclampsia in high-risk pregnant women

Costantine, M. M., Cleary, K., & Eunice Kennedy Shriver National Institute of Child Health and Human Development OPRU Network (2013). Pravastatin for the prevention of preeclampsia in high-risk pregnant women. Obstetrics and Gynecology, 121(2 Pt 1), 349-53. doi: 10.1097/AOG.0b013e31827d8ad5. (PMID: 23344286)

A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS

Pillai, V. C., Strom, S. C., Caritis, S. N., & Venkataramanan, R. (2013). A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 74, 126-32. doi: 10.1016/j.jpba.2012.10.016. (PMID: 23245243)

Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: A comparison with adult human hepatocytes

Sharma, S., Ellis, E. C., Gramignoli, R., Dorko, K., Tahan, V., Hansel, M., Mattison, D. R., Caritis, S. N., Hines, R. N., Venkataramanan, R., & Strom, S. C. (2013). Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: A comparison with adult human hepatocytes. Drug Metabolism and Disposition, 41(2), 296-304. doi: 10.1124/dmd.112.044891. (PMID: 23129211)

Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism

Cuppett, C. D., Zhao, Y., Caritis, S., Zhang, S., Zhao, W., & Venkataramanan, R. (2013). Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism. American Journal of Obstetrics and Gynecology, 208(1), 86.e1-6. doi: 10.1016/j.ajog.2012.09.021. (PMID: 23063018)

Antenatal thyroid disease and pharmacotherapy in pregnancy

Clark, S. N., & Hankins, G. D. (2013). Antenatal thyroid disease and pharmacotherapy in pregnancy. In D. Mattison (Ed.), Clinical pharmacology in pregnancy. London, UK: Elsevier.

Pharmacogenomics in pregnancy

Haas, D. M., & Flockhart, D. A. (2013). Pharmacogenomics in pregnancy. In D. R. Mattison (Ed.), Clinical pharmacology during pregnancy (pp. 113-128). London, UK: Elsevier, Inc.

Impact of pregnancy on maternal pharmacokinetics of medications

Hebert, M. F. (2013). Impact of pregnancy on maternal pharmacokinetics of medications. In D. R. Mattison (Ed.), Clinical pharmacology during pregnancy. London, Elsevier, Inc.

Fetal drug therapy

Rytting, E., & Ahmed, M. S. (2013). Fetal drug therapy. In D. R. Mattison (Ed.), Clinical pharmacology during pregnancy. London, UK: Elsevier, Inc.