Obstetric-Fetal Pharmacology Research Centers

Rationale and Design for an Investigation to Optimize SSRI Antidepressant: Treatment for Pregnant Women with Depression

Avram M.J., Stika C.S., Rasmussen-Torvik L.J., Ciolino J.D., Pinheiro E., George A.L. Jr., Wisner K.L. (2016). Rationale and Design for an Investigation to Optimize SSRI Antidepressant: Treatment for Pregnant Women with Depression . Clin Pharmacol Ther. doi: 10.1002/cpt.375. (PMID: 27037844 )

The early developments of preeclampsia drugs. Expert Opinion on Investigational Drugs

Costantine MM, Annath, C (2016). The early developments of preeclampsia drugs. Expert Opinion on Investigational Drugs. (PMID: 27253272)

Should we add pravastatin to aspirin for preeclampsia prevention in high- risk women?

MARRS, CAROLINE C. MD; COSTANTINE, MAGED M. MD (2016). Should we add pravastatin to aspirin for preeclampsia prevention in high- risk women?. Clinical Obstetrics & Gynecology. doi: 10.1097/GRF.0000000000000248.

Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: a pilot randomized controlled trial.

Costantine M. M., Cleary K., Hebert M. F., Ahmed M. S., Brown L. M., Ren Z., Easterling T. R., Haas D. M., Haneline L. S., Caritis S. N., Venkataramanan R., West H., D'Alton M., Hankins G. (2015). Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: a pilot randomized controlled trial. American Journal of Obstetrics & Gynecology. doi: 10.1016/j.ajog.2015.12.038. (PMID: 26723196)

Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC-MS/MS.

Zhang, X., Wang, X., Vernikovskaya, D. I., Fokina, V. M., Nanovskaya, T. N., Hankins, G. D., & Ahmed, M. S. (2015). Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC-MS/MS. Biomedical Chromatography, 29(4), 560-9. doi: 10.1002/bmc.3314. (PMID: 25164921)

Oseltamivir for influenza in pregnancy.

Beigi, R. H., Venkataramanan, R., & Caritis, S. N. (2014). Oseltamivir for influenza in pregnancy. Seminars in Perinatology, 38(8), 503-507. doi: 10.1053/j.semperi.2014.08.015. (PMID: 25281358)

Seminars in Perinatology

Seminars in Perinatology, 210(2):128.e1-6. doi: 10.1016/j.ajog.2013.10.008.

Challenges of studying drugs in pregnancy for off-label indications: Pravastatin for preeclampsia prevention.

Cleary, K. L., Roney, K., & Costantine, M. (2014). Challenges of studying drugs in pregnancy for off-label indications: Pravastatin for preeclampsia prevention. Seminars in Perinatology, 38(8), 523-527. doi: 10.1053/j.semperi.2014.08.019. (PMID: 25315293)

Pharmacological management of hypertension in pregnancy.

Easterling, T. R. (2014). Pharmacological management of hypertension in pregnancy. Seminars in Perinatology, 38(8), 487-495. doi: 10.1053/j.semperi.2014.08.016. (PMID: 25311173)

Antenatal corticosteroid therapy: Current strategies and identifying mediators and markers for response.

Falah, N., & Haas, D. M. (2014). Antenatal corticosteroid therapy: Current strategies and identifying mediators and markers for response. Seminars in Perinatology, 38(8), 528-533. doi: 10.1053/j.semperi.2014.08.018. (PMID: 25256192)

Prevention of preterm delivery with 17-hydroxyprogesterone caproate: Pharmacologic considerations.

Feghali, M., Venkataramanan, R., & Caritis, S. (2014). Prevention of preterm delivery with 17-hydroxyprogesterone caproate: Pharmacologic considerations. Seminars in Perinatology, 38(8), 516-522. doi: 10.1053/j.semperi.2014.08.013. (PMID: 25256193)

Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs.

Matok, I., Clark, S., Caritis, S., Miodovnik, M., Umans, J. G., Hankins, G., Mattison, D. R., & Koren, G. (2014). Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. Journal of Clinical Pharmacology, 54(12), 1429-1433. doi: 10.1002/jcph.369. (PMID: 25052410)

Is personalized medicine achievable in obstetrics?

Quinney, S. K., Patil, A. S., & Flockhart, D. A. (2014). Is personalized medicine achievable in obstetrics?. Seminars in Perinatology, 38(8), 534-540. doi: 10.1053/j.semperi.2014.08.017. (PMID: 25282474)

Introduction. Common drugs in pregnancy: an update from the Obstetric-Fetal Pharmacology Research Unit Network.

Ren, Z., & Haneline, L. S. (2014). Introduction. Common drugs in pregnancy: an update from the Obstetric-Fetal Pharmacology Research Unit Network. Seminars in Perinatology, 38(8), 473-474. doi: 10.1053/j.semperi.2014.08.010. (PMID: 25267278)

Gestational diabetes mellitus management with oral hypoglycemic agents.

Ryu, R. J., Hays, K. E., & Hebert, M. F. (2014). Gestational diabetes mellitus management with oral hypoglycemic agents. Seminars in Perinatology, 38(8), 508-515. doi: 10.1053/j.semperi.2014.08.012. (PMID: 25315294)

Identification of CYP3A7 for glyburide metabolism in human fetal livers.

Shuster, D. L., Risler, L. J., Prasad, B., Calamia, J. C., Voellinger, J. L., Kelly, E. J., Unadkat, J. D., Hebert, M. F., Shen, D. D., Thummel, K. E., Mao, Q. (2014). Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochemical Pharmacology, 92(4), 690-700. doi: 10.1016/j.bcp.2014.09.025. (PMID: 25450675)

Basic obstetric pharmacology.

Zhao, Y., Hebert, M. F., & Venkataramanan, R. (2014). Basic obstetric pharmacology. Seminars in Perinatology, 38(8), 475-486. doi: 10.1053/j.semperi.2014.08.011. (PMID: 25281357)

Taste of a pill: Organic cation transporter-3 (OCT3) mediates metformin accumulation and secretion in salivary glands.

Lee, N., Duan, H., Hebert, M. F., Liang, C. J., Rice, K. M., & Wang, J. (2014). Taste of a pill: Organic cation transporter-3 (OCT3) mediates metformin accumulation and secretion in salivary glands. Journal of Biology and Chemistry, 289(39), 27055-27064. doi: 10.1074/jbc.M114.570564. (PMID: 25107910)

Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins.

Schelleman, H., Han, X., Brensinger, C. M., Quinney, S. K., Bilker, W. B., Flockhart, D. A., Li, L., & Hennessy, S. (2014). Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. British Journal of Clinical Pharmacology, 78(3), 639-648. doi: 10.1111/bcp.12353. (PMID: 24548191)

Quantitative determination of telavancin in pregnant baboon plasma by solid-phase extraction and LC-ESI-MS.

Wang, X., Paul, J. A., Nanovskaya, T. N., Hankins, G. D., & Ahmed, M. S. (2014). Quantitative determination of telavancin in pregnant baboon plasma by solid-phase extraction and LC-ESI-MS. Pharmaceutical and Biomedical Analysis, 98, 107-112. doi: 10.1016/j.jpba.2014.04.030. (PMID: 24905291)

Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age.

Shuster, D. L., Risler, L. J., Liang, C. K., Rice, K. M., Shen, D. D., Hebert, M. F., Thummel, K. E., & Mao, Q. (2014). Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age. Journal of Pharmacology and Experimental Therapeutics, 350(2), 425-434. doi: 10.1124/jpet.114.213470. (PMID: 24898265)

Stability of hydroxyprogesterone caproate alone and in a compounded pharmaceutical product.

Zhao, Y., Bettinger, J., Caritis, S., & Venkataramanan, R. (2014). Stability of hydroxyprogesterone caproate alone and in a compounded pharmaceutical product. American Journal of Health-System Pharmacy, 71(13), 1120-1127. doi: 10.2146/ajhp130466. (PMID: 24939502)

Pharmacokinetics of indomethacin in pregnancy.

Rytting, E., Nanovskaya, T. N., Wang, X., Vernikovskaya, D. I., Clark, S. M., Cochran, M., Abdel-Rahman, S. M., Venkataramanan, R., Caritis, S. N., Hankins, G. D., Ahmed, M. S. (2014). Pharmacokinetics of indomethacin in pregnancy. Clinical Pharmacokinetics, 53(6), 545-51. doi: 10.1007/s40262-014-0133-6. (PMID: 24493205)

Pharmacokinetics of doxorubicin in pregnant women.

Ryu, R. J., Eyal, S., Kaplan, H. G., Akbarzadeh, A., Hays, K., Puhl, K., Easterling, T. R., Berg, S. L., Scorsone, K. A., Feldman, E. M., Umans, J. G., Miodovnik, M., & Hebert, M. F. (2014). Pharmacokinetics of doxorubicin in pregnant women. Cancer Chemotherapy and Pharmacology, 73(4), 789-797. doi: 10.1007/s00280-014-2406-z. (PMID: 24531558)

Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth

Caritis, S. N., Venkataramanan, R., Thom, E., Harper, M., Klebanoff, M. A., Sorokin, Y., Thorp, J. M. Jr., Varner, M. W., Wapner, R. J., Iams, J. D., Carpenter, M. W., Grobman, W. A., Mercer, B. M., Sciscione, A., Rouse, D. J., Ramin, S., & Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network and Obstetric-Fetal Pharmacology Research Units Network. (2014). Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth. American Journal of Obstetrics and Gynecology, 210(2), 128.e1-6. doi: 10.1016/j.ajog.2013.10.008. (PMID: 24113254)

Gestational diabetes induces alterations in the function of neonatal endothelial colony-forming cells

Blue, E. K., DiGiuseppe, R., Derr-Yellin, E., Acosta, J. C., Pay, S. L., Hanenberg, H., Schellinger, M. M., Quinney, S. K., Mund, J. A., Case, J., & Haneline, L. S. (2014). Gestational diabetes induces alterations in the function of neonatal endothelial colony-forming cells. Pediatric Research, 210(1), 47.e1-7. doi: 10.1016/j.ajog.2013.09.039. (PMID: 24232636)

Quality assessment of compounded 17-hydroxyprogesterone caproate

Chang, J., Zhao, Y., Zhao, W., Venkataramanan, R., Caritis, S. N., & Obstetrical-Fetal Pharmacology Research Units Network (2014). Quality assessment of compounded 17-hydroxyprogesterone caproate. American Journal of Obstetrics and Gynecology, 75(2), 266-272. doi: 10.1016/j.ajog.2013.09.039. (PMID: 24200163)

Pharmacogenetics and individualizing drug treatment during pregnancy

Haas, D. M. (2014). Pharmacogenetics and individualizing drug treatment during pregnancy. Pharmacogenomics, 15(1), 69-78. doi: 10.2217/pgs.13.228. (PMID: 24329192)

Tacrolimus Placental Transfer at Delivery and Neonatal Exposure through Breast Milk

Zheng, S., Easterling, T. R., Hays, K., Umans, J. G., Miodovnik, M., Clark, S., Calamia, J. C., Thummel, K. E., Shen, D. D., Davis, C. L., Hebert, M. F. (2013). Tacrolimus Placental Transfer at Delivery and Neonatal Exposure through Breast Milk. British Journal of Clinical Pharmacology, 76(6), 988-96. doi: 10.1111/bcp.12122. (PMID: 23528073)

Duration of cisplatin excretion in breast milk

Hays, K. E., Ryu, R. J., Swisher, E. M., Reed, E., McManus, T., Rybeck, B., Petros, W. P., & Hebert, M. F. (2013). Duration of cisplatin excretion in breast milk. Journal of Human Lactation, 29(4), 469-72. doi: 10.1177/0890334413479671. (PMID: 23492761)

Transplacental transfer and distribution of pravastatin

Nanovskaya, T. N., Patrikeeva, S. L., Paul, J., Costantine, M. M., Hankins, G. D., & Ahmed, M. S. (2013). Transplacental transfer and distribution of pravastatin. American Journal of Obstetrics and Gynecology, 209(4), 373.e1-5. doi: 10.1016/j.ajog.2013.05.038. (PMID: 24070396)

Reply: To PMID 23453884

Caritis, S. N., Zhao, Y., Venkataramanan, R., & Bettinger, J. (2013). Reply: To PMID 23453884. American Journal of Obstetrics and Gynecology, 209(3), 285-6. doi: 10.1016/j.ajog.2013.04.038. (PMID: 23643571)

Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography-mass spectrometry

Wang, X., Rytting, E., Abdelrahman, D. R., Nanovskaya, T. N., Hankins, G. D., & Ahmed, S. (2013). Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography-mass spectrometry. Biomedical Chromatography, 27(7), 866-73. doi: 10.1002/bmc.2873. (PMID: 23401067)

A Pharmacologic Approach to the Use of Glyburide in Pregnancy

Caritis, S. N., & Hebert, M. F. (2013). A Pharmacologic Approach to the Use of Glyburide in Pregnancy. Obstetrics and Gynecology, 121(6), 1309-12. doi: 10.1097/AOG.0b013e31829007f0. (PMID: 23812467)

Qualitative and quantitative measures of various compounded formulations of 17-alpha hydroxyprogesterone caproate

Caritis, S. N., Zhao, Y., Bettinger, J., & Venkataramanan, R. (2013). Qualitative and quantitative measures of various compounded formulations of 17-alpha hydroxyprogesterone caproate. American Journal of Obstetrics and Gynecology, 208(6), 470.e1-5. doi: 10.1016/j.ajog.2013.02.028. (PMID: 23453884)

A liquid chromatography method with single quadrupole mass spectrometry for quantitative determination of indomethacin in maternal plasma and urine of pregnant patients

Wang, X., Vernikovskaya, D. I., Nanovskaya, T. N., Rytting, E., Hankins, G. D., & Ahmed, M. S. (2013). A liquid chromatography method with single quadrupole mass spectrometry for quantitative determination of indomethacin in maternal plasma and urine of pregnant patients. Journal of Pharmaceutical and Biomedical Analysis, 78-79, 123-8. doi: 10.1016/j.jpba.2013.02.006. (PMID: 23474812)

Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic

Haas, D. M., Quinney, S. K., Clay, J., Renbarger, J. L., Hebert, M. F., Clark, S., Umans, J., & Caritis, S. N., for the Obstetric-Fetal Pharmacology Research Units Network (2013). Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic. American Journal of Perinatology, 30(4), 275-81. doi: 10.1055/s-0032-1323590. (PMID: 22875663)

Interpreting tacrolimus concentrations during pregnancy and postpartum

Hebert, M. F., Zheng, S., Hays, K., Shen, D. D., Davis, C. L., Umans, J. G., Miodovnik, M., Thummel, K. E., & Easterling, T. R. (2013). Interpreting tacrolimus concentrations during pregnancy and postpartum. Transplantation, 95(7), 908-15. doi: 10.1097/TP.0b013e318278d367. (PMID: 23274970)

A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women

Ke, A. B., Nallani, S. C., Zhao, P., Rostami-Hodjegan, A., Isoherranen, N., & Unadkat, J. D. (2013). A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women. Drug Metabolism and Disposition, 41(4), 801-13. doi: 10.1124/dmd.112.050161. (PMID: 23355638)

The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration

Haas, D. M., Dantzer, J., Lehmann, A. S., Philips, S., Skaar, T. C., McCormick, C. L., Hebbring, S. J., Jung, J., & Li, L. (2013). The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration. American Journal of Obstetrics and Gynecology, 208(3), 215.e1-6. doi: 10.1016/j.ajog.2012.12.031. (PMID: 23295978)

Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy

Matok, I., Clark, S., Caritis, S., Miodovnik, M., Umans, J., Hankins, G., & Koren, G. (2013). Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy. Journal of Clinical Pharmacology, 53(3), 334-8. doi: 10.1177/0091270012445207. (PMID: 23444286)

Pravastatin for the prevention of preeclampsia in high-risk pregnant women

Costantine, M. M., Cleary, K., & Eunice Kennedy Shriver National Institute of Child Health and Human Development OPRU Network (2013). Pravastatin for the prevention of preeclampsia in high-risk pregnant women. Obstetrics and Gynecology, 121(2 Pt 1), 349-53. doi: 10.1097/AOG.0b013e31827d8ad5. (PMID: 23344286)

A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS

Pillai, V. C., Strom, S. C., Caritis, S. N., & Venkataramanan, R. (2013). A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 74, 126-32. doi: 10.1016/j.jpba.2012.10.016. (PMID: 23245243)

Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: A comparison with adult human hepatocytes

Sharma, S., Ellis, E. C., Gramignoli, R., Dorko, K., Tahan, V., Hansel, M., Mattison, D. R., Caritis, S. N., Hines, R. N., Venkataramanan, R., & Strom, S. C. (2013). Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: A comparison with adult human hepatocytes. Drug Metabolism and Disposition, 41(2), 296-304. doi: 10.1124/dmd.112.044891. (PMID: 23129211)

Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism

Cuppett, C. D., Zhao, Y., Caritis, S., Zhang, S., Zhao, W., & Venkataramanan, R. (2013). Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism. American Journal of Obstetrics and Gynecology, 208(1), 86.e1-6. doi: 10.1016/j.ajog.2012.09.021. (PMID: 23063018)

Antenatal thyroid disease and pharmacotherapy in pregnancy

Clark, S. N., & Hankins, G. D. (2013). Antenatal thyroid disease and pharmacotherapy in pregnancy. In D. Mattison (Ed.), Clinical pharmacology in pregnancy. London, UK: Elsevier.

Pharmacogenomics in pregnancy

Haas, D. M., & Flockhart, D. A. (2013). Pharmacogenomics in pregnancy. In D. R. Mattison (Ed.), Clinical pharmacology during pregnancy (pp. 113-128). London, UK: Elsevier, Inc.

Impact of pregnancy on maternal pharmacokinetics of medications

Hebert, M. F. (2013). Impact of pregnancy on maternal pharmacokinetics of medications. In D. R. Mattison (Ed.), Clinical pharmacology during pregnancy. London, Elsevier, Inc.

Fetal drug therapy

Rytting, E., & Ahmed, M. S. (2013). Fetal drug therapy. In D. R. Mattison (Ed.), Clinical pharmacology during pregnancy. London, UK: Elsevier, Inc.

The status of pharmacometrics in pregnancy: Highlights from the 3rd American Conference on Pharmacometrics

van Hasselt, J. G., Andrew, M. A., Hebert, M. F., Tarning, J., Vicini, P., & Mattison, D. R. (2012). The status of pharmacometrics in pregnancy: Highlights from the 3rd American Conference on Pharmacometrics. British Journal of Clinical Pharmacology, 74(6), 932-9. doi: 10.1111/j.1365-2125.2012.04280.x. (PMID: 22452385)

Pharmacokinetics of tacrolimus during pregnancy

Zheng, S., Easterling, T. R., Umans, J. G., Miodovnik, M., Calamia, J. C., Thummel, K. E., Shen, D. D., Davis, C. L., & Hebert, M. F. (2012). Pharmacokinetics of tacrolimus during pregnancy. Therapeutic Drug Monitoring, 34(6), 660-70. doi: 10.1097/FTD.0b013e3182708edf. (PMID: 23007747)

Pharmacology and placental transport of 17-hydroxyprogesterone caproate in singleton gestation

Caritis, S. N., Sharma, S., Venkataraman, R., Hankins, G., Miodovnik, M., Hebert, M. F., Umans, J. G., Benedetti, T., Mattison, D., Zajicek, A., Fischer, D., Jackson, A., & Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetrical-Fetal Pharmacology Research Units Network (2012). Pharmacology and placental transport of 17-hydroxyprogesterone caproate in singleton gestation. American Journal of Obstetrics and Gynecology, 207(5), 398.e1–8. doi: 10.1016/j.ajog.2012.08.015. (PMID: 22967833)

Pharmacogenetics and other reasons why drugs can fail in pregnancy: higher dose or different drug?

Haas, D. M., & D’Alton, M. (2012). Pharmacogenetics and other reasons why drugs can fail in pregnancy: higher dose or different drug?. Obstetrics and Gynecology, 120(5), 1176-9. doi: 10.1097/AOG.0b013e3182698538. (PMID: 23090536)

Transplacental transfer of oseltamivir carboxylate

Nanovskaya, T. N., Patrikeeva, S. L., Zhan, Y., Hankins, G. D., & Ahmed, M. S. (2012). Transplacental transfer of oseltamivir carboxylate. The Journal of Maternal-Fetal & Neonatal Medicine, 25(11), 231-5. doi: 10.3109/14767058.2012.693993. (PMID: 22590979)

Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy

Costantine, M. M., Matok, I., Chiossi, G., Clark, S., Miodovnik, M., Umans, J. G., Caritis, S., Hankins, G. D. V., & Koren, G. (2012). Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. Therapeutic Drug Monitoring, 34(5), 569-73. (PMID: 22972538)

Tocolytic therapy for preterm delivery: A systematic review and network meta-analysis

Haas, D. M., Caldwell, D. M., Kirkpatrick, P., McIntosh, J. J., & Welton, N. J. (2012). Tocolytic therapy for preterm delivery: A systematic review and network meta-analysis. BMJ, 345, e6226, doi: 10.1136/bmj.e6226. (PMID: 23048010)

Transplacental transfer of vancomycin and telavancin

Nanovskaya, T. N., Patrikeeva, S. L., Zhan, Y., Fokina, V. M., Hankins, G. D., & Ahmed, S. (2012). Transplacental transfer of vancomycin and telavancin. American Journal of Obstetrics and Gynecology, 207(4), 331.e1-6. doi: 10.1016/j.ajog.2012.06.064. (PMID: 22867688)

The current state of therapeutic drug trials in pregnancy

Endicott, S., & Haas, D. M. (2012). The current state of therapeutic drug trials in pregnancy. Clinical Pharmacology and Therapeutics, 92(2), 149-50. doi: 10.1038/clpt.2012.81. (PMID: 22814658)

The impact of drug metabolizing enzyme polymorphisms on outcomes after antenatal corticosteroid use

Haas, D. M., Lehmann, A. S., Skaar, T., Philips, S., McCormick, C. L., Beagle, K., Hebbring, S. J., Dantzer, J., Li, L., & Jung, J. (2012). The impact of drug metabolizing enzyme polymorphisms on outcomes after antenatal corticosteroid use. American Journal of Obstetrics and Gynecology, 206(5), 447.e17-24. doi: 10.1016/j.ajog.2012.02.016. (PMID: 22445700)

A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic

Haas, D. M., Quinney, S. K., McCormick, C. L., Jones, D. R., & Renbarger, J. L. (2012). A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic. The Journal of Maternal-Fetal & Neonatal Medicine, 25(4), 419-23. doi: 10.3109/14767058.2011.583700. (PMID: 21644845)

Metabolism of 17alpha-hydroxyprogesterone caproate by human placental mitochondria

Fokina, V. M., Zharikova, O. L., Hankins, G. D., Ahmed, M. S., & Nanovskaya, T. N. (2012). Metabolism of 17alpha-hydroxyprogesterone caproate by human placental mitochondria. Reproduction Science, 19(3), 290-7. doi: 10.1177/1933719111419248. (PMID: 22138546)

Review of NVP and HG and early pharmacotherapeutic intervention

Clark, S. M., Costantine, M. M., & Hankins, G. D. V. (2012). Review of NVP and HG and early pharmacotherapeutic intervention. Obstetrics and Gynecology International, Volume 2012 (2012), Article ID 252676, doi: 10.1155/2012/252676. (PMID: 22190950)

Pharmacogenetics of obstetric therapeutics

Haas, D. M., & Renbarger, J. L. (2012). Pharmacogenetics of obstetric therapeutics. In R. B. Altman, D. Flockhart, & D. B. Goldstein (Eds.), Principles of pharmacogenetics and pharmacogenomics (pp. 202-216). Cambridge: Cambridge University Press.

Increased apoptosis in chorionic trophoblasts of human fetal membranes with labor at term

Harirah, H. M., Borahay, M. A., Zaman, W., Ahmed, M. S., & Hankins, G. D. (2012). Increased apoptosis in chorionic trophoblasts of human fetal membranes with labor at term. International Journal of Clinical Medicine, 3, 136-142.

Drugs during pregnancy and lactation: New solutions to serious challenges

Koren, G., Clark, S., & Matsui, D. (2012). Drugs during pregnancy and lactation: New solutions to serious challenges. Obstetrics and Gynecology International, Volume 2012 (2012), Article ID 206179, doi: 10.1155/2012/206179.

Compartmental pharmacokinetics of immediate release nifedipine in pregnancy: Variability in absorption

Nader, A. M., Caritis, S. N., Hebert, M. F., Clark, S. M., Flockhart, D. A., & Quinney, S. K. (2012). Compartmental pharmacokinetics of immediate release nifedipine in pregnancy: Variability in absorption. Clinical Pharmacology and Therapeutics, 91(S1), PIII-109,

A semi-mechanistic metabolism model of CYP3A substrates in pregnancy: Predicting changes in midazolam and nifedipint pharmacokinetics

Quinney, S. K., Mohamed, A. N., Hebert, M. F., Haas, D. M., Clark, S., Umans, J. G., Caritis, S. N., & Li, L. (2012). A semi-mechanistic metabolism model of CYP3A substrates in pregnancy: Predicting changes in midazolam and nifedipint pharmacokinetics. CPT: Pharmacometrics & Systems Pharmacology, 1: e2, doi: 10.1038/psp.2012.5. (PMID: 23835882)

Opioid exposure and birth defects

Haas, D. M. (2011). Opioid exposure and birth defects. American Journal of Obstetrics and Gynecology, 205(3): e9-e10. author reply e10-1, doi: 10.1016/j.ajog.2011.06.031. (PMID: 22071073)

Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu

Simhan, H. N., Himes, K. P., Venkataramanan, R., & Bodnar, L. M. (2011). Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. American Journal of Obstetrics and Gynecology, 205(1), 61.e1-e7. doi: 10.1016/j.ajog.2011.03.039. (PMID: 21600548)

Pharmacokinetics of Oseltamivir among pregnant and non-pregnant women

Beigi, R. H., Kelong, H., Venkataramanan, R., Hankins, G. D., Clark, S., Herbert, M. F., Easterling, T., Zajicek, A., Ren, Z., Mattison, D. R., & Caritis, S. N. (2011). Pharmacokinetics of Oseltamivir among pregnant and non-pregnant women. American Journal of Obstetrics and Gynecology, 204(6 Suppl 1), S84-8. doi: 10.1016/j.ajog.2011.03.002. (PMID: 21492826)

Pharmacotherapeutic management of nicotine dependence in pregnancy

Clark, S. M., & Nakad, R. (2011). Pharmacotherapeutic management of nicotine dependence in pregnancy. Obstetrics and Gynecology Clinics of North America, 38(2), 297-311. doi: 10.1016/j.ogc.2011.02.017. (PMID: 21575802)

Pharmacotherapy and pregnancy: Highlights from the Third International Conference for Individualized Pharmacotherapy in Pregnancy

Haas, D. M., Gallauresi, B., Shields, K., Zeitlin, D., Clark, S. M., Hebert, M. F., Ren, A., Nallani, S. C., Meslin, E. M., Feibus, K. B., Koren, G., Goebel, W. S., Easterling, T., Denne, A. C., Flockhart, D. A., & Renbarger, J. L. (2011). Pharmacotherapy and pregnancy: Highlights from the Third International Conference for Individualized Pharmacotherapy in Pregnancy. Clinical and Translational Science, 4(3), 204-9. doi: 10.1111/j.1752-8062.2011.00280.x. (PMID: 21707952)

Human breast milk as a source of DNA for amplification

Haas, D. M., Daum, M., Skaar, T., Philips, S., Miracle, D., & Renbarger, J. L. (2011). Human breast milk as a source of DNA for amplification. Journal of Clinical Pharmacology, 51(4), 616-9. doi: 10.1177/0091270010370847. (PMID: 20498289)

Collection of human genomic DNA from neonates: A comparison between umbilical cord blood and buccal swabs

Lehmann, A. S., Haas, D. M., McCormick, C. L., Skaar, T. C., & Renbarger, J. L. (2011). Collection of human genomic DNA from neonates: A comparison between umbilical cord blood and buccal swabs. American Journal of Obstetrics and Gynecology, 204(4), 362.e1-6. doi: 10.1016/j.ajog.2010.12.013. (PMID: 21324432)

Gestational diabetes mellitus alters maternal and neonatal circulating endothelial progenitor cell subsets

Acosta, J. C., Haas, D. M., Saha, C. K., Dimeglio, L. A., Ingram, D. A., & Haneline, L. S. (2011). Gestational diabetes mellitus alters maternal and neonatal circulating endothelial progenitor cell subsets. American Journal of Obstetrics and Gynecology, 204(3), 254.e8-e15. doi: 10.1016/j.ajog.2010.10.913. (PMID: 21167470)

Maternal ethnicity influences on neonatal respiratory outcomes after antenatal corticosteroid use for anticipated preterm delivery

Haas, D. M., Sischy, A. C., McCullough, W., & Simsiman, A. J. (2011). Maternal ethnicity influences on neonatal respiratory outcomes after antenatal corticosteroid use for anticipated preterm delivery. The Journal of Maternal-Fetal & Neonatal Medicine, 24(3), 516-20. doi: 10.3109/14767058.2010.506228. (PMID: 20672908)

Pharmacokinetics of metronidazole in pregnant patients with bacterial vaginosis

Wang, X., Nanovskaya, T. N., Zhan, Y., Abdel-Rahman, S. M., Jasek, M. B., Hankins, G. D. V., & Ahmed, M. S. (2011). Pharmacokinetics of metronidazole in pregnant patients with bacterial vaginosis. The Journal of Maternal-Fetal & Neonatal Medicine, 24(3), 444-448. doi: 10.3109/14767058.2010.497573. (PMID: 20608802)

Pregnancy decreases rat CYP1A2 activity and expression

Walker, A. A., Dickmann, L., & Isoherranen, N. (2011). Pregnancy decreases rat CYP1A2 activity and expression. Drug Metabolism and Disposition, 39(1), 4-7. doi: 10.1124/dmd.110.035766. (PMID: 20921303)

Pharmacokinetics of indomethacin in pregnant women with preterm labor

Wang, X., Rytting, E., Nanovskaya, T. N., Patrikeeva, S. L., Clark, S., Jasek, M. B., Venkataramanan, R., Caritis, S., Hankins, G. D. V., & Ahmed, M. S. (2011). 180: Pharmacokinetics of indomethacin in pregnant women with preterm labor. American Journal of Obstetrics & Gynecology, Volume 204 , Issue 1 , S83. doi: http://dx.doi.org/10.1016/j.ajog.2010.10.196.

Pharmacokinetics of famotidine in pregnant women

Wang, X., Zhan, Y., Rytting, E., Patrikeeva, S. L., Nanovskaya, T. N., Clark, S., Jackson, A., Venkataramanan, R., Caritis, S., Hankins, G. D. V., & Ahmed, M. S. (2011). 150: Pharmacokinetics of famotidine in pregnant women. American Journal of Obstetrics & Gynecology, Volume 204, Issue 1, S72–S73. doi: http://dx.doi.org/10.1016/j.ajog.2010.10.166.

From no to yes: The history and ethics of including pregnant women in clinical trials

Haas, D. M. (2011). From no to yes: The history and ethics of including pregnant women in clinical trials. Clinical Investigation, 1(10), 1349-51. doi: 10.4155/CLI.11.125.

The placenta as a functional barrier to fetal drug exposure

Nanovskaya, T. N., Hankins, G. D. V., & Ahmed, M. S. (2011). The placenta as a functional barrier to fetal drug exposure. In H. Kay, D. M. Nelson, & Y. Wang (Eds.), The placenta from development to disease, Hoboken, NJ: Wiley-Blackwell, 303-9.

Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: A randomized placebo-controlled trial

Koren, G., Clark, S. M., Hankins, G. D. V., Caritis, S. N., Miodovnik, M., & Mattison, D. R. (2010). Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: A randomized placebo-controlled trial. American Journal of Obstetrics and Gynecology, 203(6), 571.e1-571.e7. doi: 10.1016/j.ajog.2010.07.030. (PMID: 20843504)

Atenolol Pharmacokinetics and excretion in breast milk during the first 6-8 months postpartum

Eyal, S., Kim, J. D., Anderson, G. D., Buchanan, M. L., Brateng, D. A., Carr, D., Woodrum, D. E., Easterling, T. R., & Hebert, M. F. (2010). Atenolol Pharmacokinetics and excretion in breast milk during the first 6-8 months postpartum. Journal of Clinical Pharmacology, 50(11), 1301-1309. doi: 10.1177/0091270009358708. (PMID: 20145263)

Pharmacodynamics of clonidine therapy in pregnancy: A heterogeneous maternal response impacts fetal growth

Rothenberger, S., Carr, D., Brateng, D., Hebert, M., & Easterling, T. (2010). Pharmacodynamics of clonidine therapy in pregnancy: A heterogeneous maternal response impacts fetal growth. American Journal of Hypertension, 23, 1234-1240. doi: 10.1038/ajh.2010.159. (PMID: 20725050)

Maternal serum folate species in early pregnancy and risk of preterm birth

Bodnar, L. M., Himes, K. P., Venkataramanan, R., Chen, J. Y., Evans, R. W., Meyer, J. L., & Simhan, H. N. (2010). Maternal serum folate species in early pregnancy and risk of preterm birth. American Journal of Clinical Nutrition, 92(4), 864-871. doi: 10.3945/ajcn.2010.29675. (PMID: 20739422)

CYP2D6 mediates 4-hydroxylation of clonidine in vitro: Implication for pregnancy-induced changes in clonidine clearance

Claessens, A., Risler, L., Eyal, S., Shen, D., Easterling, T., & Hebert, M. (2010). CYP2D6 mediates 4-hydroxylation of clonidine in vitro: Implication for pregnancy-induced changes in clonidine clearance. Drug Metabolism and Disposition, 38(9), 1393-1396. doi: 10.1124/dmd.110.033878. (PMID: 20570945)

Increased Glyburide Clearance in the Pregnant Mouse Model

Zhou, L., Zhang, Y., Hebert, M., Unadkat, J., & Mao, Q. (2010). Increased Glyburide Clearance in the Pregnant Mouse Model. Drug Metabolism and Disposition, 38(9), 1403-1406. doi: 10.1124/dmd.110.033837. (PMID: 20558597)

Pharmacokinetics of Metformin during pregnancy

Eyal, S., Easterling, T. R., Carr, D., Umans, J. G., Miodovnik, M., Hankins, G. D., Clark, S. M., Risler, L., Wang, J., Kelly, E. J., Shen, D. D., & Hebert, M. F. (2010). Pharmacokinetics of Metformin during pregnancy. Drug Metabolism and Disposition, 38, 833-840. doi: 10.1124/dmd.109.031245. (PMID: 20118196)

Metabolism of 17alpha-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes

Sharma, S., Ellis, E. C., Dorko, K., Zhang, S., Mattison, D. R., Caritis, S. N., Venkataramanan, R., & Strom, S. C. (2010). Metabolism of 17alpha-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes. Drug Metabolism and Disposition, 38(5), 723-727. doi: 10.1124/dmd.109.029918. (PMID: 20097724)

Contributions of human cytochrome P450 enzymes to Glyburide metabolism

Zhou, L., Naraharisetti, S. B., Liu, L., Wang, H., Lin, Y. S., Isoherranen, N., Unadkat, J. D., Hebert, M. F., & Mao, Q. (2010). Contributions of human cytochrome P450 enzymes to Glyburide metabolism. Biopharmaceutics and Drug Disposition, 31(4), 228-242. doi: 10.1002/bdd.706. (PMID: 20437462)

Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin

Hemauer, S. J., Patrikeeva, S. L., Nanovskaya, T. N., Hankins, G. D., & Ahmed, M. S. (2010). Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin. American Journal of Obstetrics and Gynecology, 202(4), 383.e1-383.e7. doi: 10.1016/j.ajog.2010.01.035. (PMID: 20350646)

Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms

Hemauer, S. J., Nanovskaya, T. N., Abdel-Rahman, S. Z., Patrikeeva, S. L., Hankins, G. D., & Ahmed, M. S. (2010). Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms. Biochemical Pharmacology, 79(6), 921-925. doi: 10.1016/j.bcp.2009.10.026. (PMID: 19896927)

Positron emission tomography imaging of tissue P-glycoprotein during pregnancy in the non-human primate

Chung, F. S., Eyal, S., Muzi, M., Link, J. M., Mankoff, D. A., Kaddoumi, A., O’Sullivan, F., Hsiao, P., & Unadkat, J. D. (2010). Positron emission tomography imaging of tissue P-glycoprotein during pregnancy in the non-human primate. British Journal of Pharmacology, 159(2), 394-404. doi: 10.1111/j.1476-5381.2009.00538.x. (PMID: 20002098)

Biotransformation of medications by human placenta

Zharikova, O. L., Nanovskaya, T. N., & Ahmed, M. S. (2010). Biotransformation of medications by human placenta. In S. J. Yaffe & J. V. Aranda (Eds.), Neonatal and Pediatric Pharmacology; Therapeutic Principles in Practice, 4th Edition (pp. 144-153). Philadelphia, PA: Lippincott Williams & Wilkins.

Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide

Zharikova, O. L., Fokina, V. M., Nanovskaya, T. N., Hill, R. A., Mattison, D. R., Hankins, G. D., & Ahmed, M. S. (2009). Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide. Biochemical Pharmacology, 78(12), 1483-1490. doi: 10.1016/j.bcp.2009.08.003. (PMID: 19679108)

Effect of plasma proteins on buprenorphine transfer across dually perfused placental lobule

Nanovskaya, T. N., Bowen, R. S., Patrikeeva, S. L., Hankins, G. D., & Ahmed, M. S. (2009). Effect of plasma proteins on buprenorphine transfer across dually perfused placental lobule. The Journal of Maternal-Fetal & Neonatal Medicine, 22(8), 646-653. doi: 10.1080/14767050802610328. (PMID: 19544152)

Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice

Hebert, M. F., Ma, X., Naraharisetti, S. B., Krudys, K. M., Umans, J. G., Hankins, G. D., Caritis, S. N., Miodovnik, M., Mattison, D. R., Unadkat, J. D., Kelly, E. J., Blough, D., Cobelli, C., Ahmed, M. S., Snodgrass, W. R., Carr, D. B., Easterling, T. R., Vicini, P., & Obstetric-Fetal Pharmacology Research Unit Network (2009). Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice. Clinical Pharmacology and Therapeutics, 85(6), 607–614. doi: 10.1038/clpt.2009.5. (PMID: 19295505)

Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant non-human primate

Eyal, S., Chung, F. S., Muzi, M., Link, J. M., Mankoff, D. A., Kaddoumi, A., O’Sullivan, F., Hebert, M. F., & Unadkat, J. D. (2009). Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant non-human primate. Journal of Nuclear Medicine, 50(5), 798-806. doi: 10.2967/jnumed.108.059360. (PMID: 19403878)

Clonidine pharmacokinetics in pregnancy

Buchanan, M. L., Easterling, T. R., Carr, D. B., Shen, D. D., Risler, L. J., Nelson, W. L., Mattison, D. R., & Hebert, M. F. (2009). Clonidine pharmacokinetics in pregnancy. Drug Metabolism and Disposition, 37(4), 702-705. doi: 10.1124/dmd.108.024984. (PMID: 19116263)

Simultaneous quantitation of 17a-hydroxyprogesterone caproate, 17a-hydroxyprogesterone and progesterone in human plasma using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS)

Zhang, S., Mada, S. R., Sharma, S., Torch, M., Mattison, D., Caritis, S., & Venkataramanan, R. (2008). Simultaneous quantitation of 17a-hydroxyprogesterone caproate, 17a-hydroxyprogesterone and progesterone in human plasma using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS). Journal of Pharmaceutical and Biomedical Analysis, 48(4), 1174–1180. doi: 10.1016/j.jpba.2008.08.024. (PMID: 18947956)

Profiling gene expression in human placentae of different gestational ages: An OPRU Network and UW SCOR study

Mikheev, A. M., Nabekura, T., Kaddoumi, A., Bammler, T. K., Govindarajan, R., Hebert, M. F., & Unadkat, J. D. (2008). Profiling gene expression in human placentae of different gestational ages: An OPRU Network and UW SCOR study. Reproduction Science, 15(9), 866-877. doi: 10.1177/1933719108322425. (PMID: 19050320)

Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites in human and macaque plasma

Unadkat, J. D., Chung, F., Sasongko, L., Whittington, D., Eyal, S., Mankoff, D., Collier, A. C., Muzi, M., & Link, J. (2008). Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites in human and macaque plasma. Nuclear Medicine and Biology, 35(8), 911-917. doi: 10.1016/j.nucmedbio.2008.08.001. (PMID: 19026953)

Identification of enzymes involved in the metabolism of 17a-hydroxyprogesterone caproate: An effective agent for the prevention of preterm birth

Sharma, S., Ou, J., Strom, S., Mattison, D., Caritis, S., & Venkataramanan, R. (2008). Identification of enzymes involved in the metabolism of 17a-hydroxyprogesterone caproate: An effective agent for the prevention of preterm birth. Drug Metabolism and Disposition, 36(9), 1896-18902. doi: 10.1124/dmd.108.021444. (PMID: 18573861)

Transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate

Hemauer, S. J., Yan, R., Patrikeeva, S. L., Mattison, D. R., Hankins, G. D., Ahmed, M. S., & Nanovskaya, T. N. (2008). Transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate. American Journal of Obstetrics and Gynecology, 199(2), 169.e1-169.e5. doi: 10.1016/j.ajog.2007.11.065. (PMID: 18674659)

Rapid measurement of estrogens and their metabolites in human serum by liquid chromatography-tandem mass spectrometry without derivatization

Guo, T., Gu, J., Soldin, O. P., Singh, R. J., & Soldin, S. J. (2008). Rapid measurement of estrogens and their metabolites in human serum by liquid chromatography-tandem mass spectrometry without derivatization. Clinical Biochemistry, 41(9), 736-741. doi: 10.1016/j.clinbiochem.2008.02.009. (PMID: 18358240)

Serotonin syndrome associated with triptan monotherapy

Soldin, O. P., Tonning, J. M., & Obstetric-Fetal Pharmacology Research Unit Network (2008). Serotonin syndrome associated with triptan monotherapy. New England Journal of Medicine, 358(20), 2185-2186. doi: 10.1056/NEJMc0706410. (PMID: 18480219)

Metabolism of 17alpha-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons

Yan, R., Nanovskaya, T. N., Zharikova, O. L., Mattison, D. R., Hankins, G. D., & Ahmed, M. S. (2008). Metabolism of 17alpha-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons. Biochemical Pharmacology, 75(9), 1848-1857. doi: 10.1016/j.bcp.2008.01.013. (PMID: 18329004)

Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy

Dickmann, L. J., Tay, S., Senn, T. D., Zhang, H., Visone, A., Unadkat, J. D., Hebert, M. F., & Isoherranen, N. (2008). Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Biochemical Pharmacology, 75(8), 1677-1687. doi: 10.1016/j.bcp.2008.01.012. (PMID: 18342837)

Glyburide metabolism by placentas of healthy and gestational diabetics

Jain, S., Zharikova, O. L., Ravindran, S., Nanovskya, T. N., Mattison, D. R., Hankins, G. D., & Ahmed, M. S. (2008). Glyburide metabolism by placentas of healthy and gestational diabetics. American Journal of Perinatology, 25(3), 169-174. doi: 10.1055/s-2008-1061503. (PMID: 18300189)

Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide

Nanovskaya, T. N., Patrikeeva, S., Hemauer, S., Fokina, V., Mattison, D., Hankins, G. D., Ahmed, M. S., & OPRU Network (2008). Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide. Journal of Maternal Fetal & Neonatal Medicine, 21(3), 197-207. doi: 10.1080/14767050801929901. (PMID: 18297575)

The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: An Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study

Zhou, L., Naraharisetti, S. B., Wang, H., Unadkat, J. D., Hebert, M. F., & Mao, Q. (2008). The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: An Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study. Molecular Pharmacology, 73(3), 949–959. doi: 10.1124/mol.107.041616. (PMID: 18079276)

Triptans in pregnancy

Soldin, O. P., Dahlin, J., & O'Mara, D. M. (2008). Triptans in pregnancy. Therapeutic Drug Monitoring, 30(1), 5-9. doi: 10.1097/FTD.0b013e318162c89b. (PMID: 18223456)

The effect of esterases on 17alpha-hydroxyprogesterone caproate

Yan, R., Fokina, V., Hankins, G. D., Ahmed, M. S., & Nanovskaya, T. N. (2008). The effect of esterases on 17alpha-hydroxyprogesterone caproate. American Journal of Obstetrics and Gynecology, 198(2), 229.e1-229.e5. doi: DOI: 10.1016/j.ajog.2007.07.038. (PMID: 17936237)

Human decidual cell Toll-like receptor signaling in response to endotoxin: The effect of progestins

Simhan, H. N., Chiao, J. P., Mattison, D. R., & Caritis, S. N. (2008). Human decidual cell Toll-like receptor signaling in response to endotoxin: The effect of progestins. American Journal of Obstetrics and Gynecology, 198(1), 119.e1-119.e4. doi: 10.1016/j.ajog.2007.06.022. (PMID: 17936235)

Physiologically based pharmacokinetic model of midazolam disposition during pregnancy

Andrew, M. A., Hebert, M. F., Vicini, P. (2008). Physiologically based pharmacokinetic model of midazolam disposition during pregnancy. Conference Proceedings: IEEE Engineering in Medicine and Biology Society, 2008, 5454-5457. doi: 10.1109/IEMBS.2008.4650448. (PMID: 19163951)

Simultaneous quantification of free triiodothyronine and free thyroxine by isotope dilution tandem mass spectrometry

Gu, J., Soldin, O. P., & Soldin, S. J. (2007). Simultaneous quantification of free triiodothyronine and free thyroxine by isotope dilution tandem mass spectrometry. Clinical Biochemistry, 40(18), 1386-91. doi: 10.1016/j.clinbiochem.2007.08.007. (PMID: 17936741)

Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-transhydroxy glyburide in plasma and urine: An OPRU Network study

Naraharisetti, S. B., Kirby, B. J., Hebert, M. F., Easterling, T. R., & Unadkat, J. D. (2007). Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-transhydroxy glyburide in plasma and urine: An OPRU Network study. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 860(1), 34–41. doi: 10.1016/j.jchromb.2007.10.010. (PMID: 17980680)

A model of epilepsy during pregnancy in Sprague-Dawley rats

Roesch, D., Malthankar-Phatak, G., Hintz, T., McCloskey, D., Sandberg, K., Maclusky, N., & Scharfman, H. (2007). A model of epilepsy during pregnancy in Sprague-Dawley rats. American Journal of Obstetrics and Gynecology, 197(6), S125.(Link).

Antiepileptic drug-induced neuronal cell death in the immature brain: Effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy

Kim, J., Kondratyev, A., & Gale, K. (2007). Antiepileptic drug-induced neuronal cell death in the immature brain: Effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy. Journal of Pharmacology and Experimental Therapeutics, 323(1), 165-173. doi: 10.1124/jpet.107.126250. (PMID: 17636003)

Gestation-specific thyroxine and thyroid stimulating hormone levels in the United States and worldwide

Soldin, O. P., Soldin, D., & Sastoque, M. (2007, October). Gestation-specific thyroxine and thyroid stimulating hormone levels in the United States and worldwide. Therapeutic Drug Monitoring, 29(5), 553-559. (PMID: 17898643).

Effects of manganese on thyroid hormones homeostatis: Potential links

Soldin, O. P., & Aschner, M. (2007). Effects of manganese on thyroid hormones homeostatis: Potential links. Neurotoxicology, 28(5), 951–956. doi: 10.1016/j.neuro.2007.05.003. (PMID: 17576015)

Development and validation of a high-performance liquid chromatography-mass spectrometric assay for the determination of 17a-hydroxyprogesterone caproate (17-OHPC) in human plasma

Zhang, S., Mada, S. R., Mattison, D., Caritis, S., Venkataramanan, R., & OPRU Network. (2007, September 1). Development and validation of a high-performance liquid chromatography-mass spectrometric assay for the determination of 17a-hydroxyprogesterone caproate (17-OHPC) in human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 856(102), 141–147. (PMID: 17576102).

Development and validation of a high-performance liquid chromatography-mass spectrometric assay for the determination of 17alpha-hydroxyprogesterone caproate(17-OHPC) in human plasma

Zhang, S., Mada, S. R., Mattison, D., Caritis, S., Venkataramanan, R., & Obstetric-Fetal Pharmacology Research Unit Network (2007). Development and validation of a high-performance liquid chromatography-mass spectrometric assay for the determination of 17alpha-hydroxyprogesterone caproate(17-OHPC) in human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 856(1–2), 141–147. doi: 10.1016/j.jchromb.2007.05.028. (PMID: 17576102)

Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain

Katz, I., Kim, J., Gale, K., & Kondratyev, A. (2007). Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain. Journal of Pharmacology and Experimental Therapeutics, 322(2), 494-500. doi: 10.1124/jpet.107.123133. (PMID: 17483293)

Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon

Zharikova, O. L., Ravindran, S., Nanovskaya, T. N., Hill, R. A., Hankins, G. D., & Ahmed, M. S. (2007). Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon. Biochemical Pharmacology, 73(12), 2012-2019. (PMID: 17462606)

Amoxicillin pharmacokinetics, modeling and simulations of dosage strategies

Andrew, M. A., Easterling, T. R., Carr, D. B., Shen, D., Buchanan, M. L., Rutherford, T., Bennett, R., Vicini, P., & Hebert, M. F. (2007). Amoxicillin pharmacokinetics, modeling and simulations of dosage strategies. Clinical Pharmacology and Therapeutics, 81(4), 547–556. doi: 10.1038/sj.clpt.6100126. (PMID: 17329990)

Tandem mass spectrometry improves the accuracy of free thyroxine measurements during pregnancy

Kahric-Janicic, N., Soldin, S. J., Soldin, O. P., West, T., Gu, J., & Jonklaas, J. (2007). Tandem mass spectrometry improves the accuracy of free thyroxine measurements during pregnancy. Thyroid, 17(4), 303-11. doi: 10.1089/thy.2006.0303. (PMID: 17465859)

Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain

Kim, J. S., Kondratyev, A., Tomita, Y., & Gale, K. (2007). Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain. Epilepsia, 48(Suppl 5), 19-26. doi: 10.1111/j.1528-1167.2007.01285.x. (PMID: 17910577)

Gestational changes in renal electrolyte transporters may increase lithium toxicity

Roesch, D., Shi, M., Shalkey, V., Spittler, J., Sandberg, K., Umans, J., & Miodovnik, M. (2007). Gestational changes in renal electrolyte transporters may increase lithium toxicity. American Journal of Obstetrics and Gynecology, 197(6), S125. (Link).

Effects of Lamotrigine on Apoptotic Cell Death of the Neonatal Rat Brain

Katz, I., Kim, J., Gale, K., & Kondratyev, A. (2006, December). Effects of Lamotrigine on Apoptotic Cell Death of the Neonatal Rat Brain. AES Abstract, 2.184. (Link).

Enhancement of Phenytoin-Induced Neuronal Death in Neonatal Rats by AEDs That Do Not Induce Neuronal Death When Given Alone

Kim, J., Kondratyev, A., & Gale, K. (2006, December). Enhancement of Phenytoin-Induced Neuronal Death in Neonatal Rats by AEDs That Do Not Induce Neuronal Death When Given Alone. AES Abstract, 2.182. (Link).

Identification of glyburide metabolites formed by hepatic and placental microsomes of humans and baboons

Ravindran, S., Zharikova, O. L., Hill, R. A., Nanovskaya, T. N., Hankins, G. D., & Ahmed, M. S. (2006). Identification of glyburide metabolites formed by hepatic and placental microsomes of humans and baboons. Biochemical Pharmacology, 72(12), 1730-1737. doi: 10.1016/j.bcp.2006.08.024. (PMID: 17011523)

Transfer of metformin across the dually perfused human placental lobule

Nanovskaya, T. N., Nekhayeva, I. A., Patrikeeva, S. L., Hankins, G. D., & Ahmed, M. S. (2006). Transfer of metformin across the dually perfused human placental lobule . American Journal of Obstetrics and Gynecology, 195(4), 1081-1085. doi: 10.1016/j.ajog.2006.05.047. (PMID: 16824464)

Explaining and predicting preeclampsia

Lindheimer, M. D., & Umans, J. G. (2006). Explaining and predicting preeclampsia. New England Journal of Medicine, 355(10), 1056-8. (PMID: 16957153)

Pharmacokinetics and pharmacotherapy of thionamides in pregnancy

Clark, S. M., Saade, G. R., Snodgrass, W. R., & Hankins, G. D. (2006). Pharmacokinetics and pharmacotherapy of thionamides in pregnancy. Therapeutic Drug Monitoring, 28(4), 477-483. (PMID: 16885714)

Effect of human serum albumin on transplacental transfer of glyburide

Nanovskaya, T. N., Nekhayeva, I., Hankins, G. D., & Ahmed, M. S. (2006). Effect of human serum albumin on transplacental transfer of glyburide. Biochemical Pharmacology, 72(5), 632-639. doi: 10.1016/j.bcp.2006.05.019. (PMID: 16828060)

Year epublished

Year epublished: 2005

Therapeutic drug monitoring of antithyroid drugs in pregnancy: The knowledge gaps

Koren, G., & Soldin, O. (2006, February). Therapeutic drug monitoring of antithyroid drugs in pregnancy: The knowledge gaps. Therapeutic Drug Monitoring, 28(1), 12-13. (PMID: 16418686).

Thyroid function testing in pregnancy and thyroid disease: Trimester-specific reference intervals

Soldin, O. P. (2006). Thyroid function testing in pregnancy and thyroid disease: Trimester-specific reference intervals. Therapeutic Drug Monitoring, 28(1), 8-11. (PMID: 16418685)

Manganese transport and neurotoxicity

Fitsanakis, V. A., Owens, S. E., dos Snatos, A. P. M., Soldin, O. P., & Aschner, M. (2006). Manganese transport and neurotoxicity. Metal Ions in Biology and Medicine, 9, 101-107.

Drugs during Pregnancy and Lactation: Treatment Options and Risk Assessment, 3rd edition, 2014, p 294-339

Wisner KL, Schaefer C.  Psychotropic Drugs.  In Schaefer C, Peters P, Miller RK, eds. Drugs during  Pregnancy and Lactation: Treatment Options and Risk Assessment, 3rd edition, 2014, p 294-339.

Sertraline and breastfeeding: Review and meta-analysis. Arch Women’s Mental Health 18:139-46, 2015.

1. Pinheiro E, Bogen DL, Hoxha D, Ciolino J, Wisner KL.Sertraline and breastfeeding: Review and meta-analysis. Arch Women’s Mental Health 18:139-46, 2015.

Transdermal estradiol treatment for postpartum depression:A pilot randomized trial

Wisner KL, Sit DK, Moses-Kolko EL, Driscoll KE, Prairie B, Stika CS, Eng HF, Dills JL, Luther JF,Wisniewski SR.Transdermal estradiol treatment for postpartum depression:A pilot randomized trial.J Clin Psychopharmacology 35(4):389-95, 2015.

Should pregnant women should be included in phase IV clinical drug trials?American Journal of Obstetrics & Gynecology

Briggs GG, Polifka JE, Wisner KL, Gervais E, Miller RK, Berard A, Koren G, Forinash A, Towers CV.Should pregnant women should be included in phase IV clinical drug trials?American Journal of Obstetrics & Gynecology 213:810-5, 2015.

Is third trimester serotonin reuptake inhibitor use associated with postpartum hemorrhage?

Kim DR, Pinheiro E, Luther JF, Eng HF, Dills JL, Wisniewski SR, Wisner KL.Is third trimester serotonin reuptake inhibitor use associated with postpartum hemorrhage?J Psychiatr Res 19:73:79-85, 2015.

The roles of maternal depression, serotonin reuptake inhibitor treatment, and concomitant benzodiazepine use on infant neurobehavioral functioning over the first postnatal month

Salisbury AL, O’Grady K, Battle CL, Wisner KL, Anderson GM, Stroud L, Miller-Loncar C, Young Y, Lester BM.The roles of maternal depression, serotonin reuptake inhibitor treatment, and concomitant benzodiazepine use on infant neurobehavioral functioning over the first postnatal month. Am J Psych 173:147-57, 2016.

Transdermal estradiol treatment during breastfeeding:Maternal and infant serum concentrations

Pinheiro E, Bogen DL, Hoxha D, Wisner KL. Transdermal estradiol treatment during breastfeeding:Maternal and infant serum concentrations.Arch Women’s Mental Health 19:409-13, 2016.

Antipsychotics in pregnancy: Pregnant women get sick—sick women get pregnant

Wisner KL, Jeong H, Chambers CD.  Antipsychotics in pregnancy:  Pregnant women get sick—sick women get pregnant.  JAMA Psychiatry 73:901-903, 2016.

Mindfulness based stress reduction adapted for depressed disadvantaged women in an urban federally qualified health center

Burnett-Zeigler I, Moskowitz JT, Hong SH, Wisner KL, Satyshur M. Mindfulness based stress reduction adapted for depressed disadvantaged women in an urban federally qualified health center.  Complementary Therapies in Clinical Practice 25:59-67, 2016.

Psychiatry and Obstetrics: An Imperative for Collaboration

Hoffman MC, Wisner KL.Psychiatry and Obstetrics: An Imperative for Collaboration.Am J Psych 1;174(3):205-207, 2017.

Consensus bundle on maternal mental health: Perinatal depression and anxiety

Kendig S, Keats JP, Hoffman MC, Kay LB, Miller ES, Moore Simas TA, Frieder A, Hackley B, Indman P, Raines C, Semenuk K, Wisner KL, Lemieux LA.  Consensus bundle on maternal mental health: Perinatal depression and anxiety.   Obstetrics & Gynecology 129:422-430, 2017.

Neonatal discontinuation syndrome in serotonergic antidepressant exposed neonates

Yang A, Ciolino JD, Pinheiro E, Rasmussen-Torvik LJ, Sit DK, Wisner KL.Neonatal discontinuation syndrome in serotonergic antidepressant exposed neonates.J Clin Psych 78:605-611, 2017.

Pharmacologic treatment options for hyperemesis gravidarum

Abramowitz A, Miller ES, Wisner KL.Pharmacologic treatment options for hyperemesis gravidarum. Arch Women's Mental Health 20:363-372, 2017.

Treating depression during pregnancy: Are we asking the right questions?

Angelotta C, Wisner KL.Treating depression during pregnancy: Are we asking the right questions?Birth Defects Research 109:879-887, 2017.

Corrected QTc and methadone dose and concentrations in pregnant and postpartum women

Bogen DL, Hanusa BH, Perel JM, Sherman F, Mendelson M, Wisner KL.Corrected QTc and methadone dose and concentrations in pregnant and postpartum women.J Clin Psych 78(8):e1013-e1019, 2017.

Mental Health and Behavioral Disorders in Pregnancy

Wisner KL,Sit DKY, Reynolds SK, Bogen DL, Altemus M, Pearlstein TB, Svikis D, Misra D, Miller EM:Mental Health and Behavioral Disorders in Pregnancy, in Obstetrics:Normal and Problem Pregnancies, 7^th edition.Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ERM, Driscoll DA, Berghetta V, Grobman WA, Eds; Elsevier, 2017,p 1147-1172.

Quetiapine dose adjustments in pregnant and postpartum women with bipolar disorder

Pinheiro E, Wisner KL, Clark CT.Quetiapine dose adjustments in pregnant and postpartum women with bipolar disorder.J Clin Psychopharm 38(1):89-91, 2018.

Looking beyond the pain: Can effective labor analgesia prevent the development of postpartum depression?

2018 Toledo P, Miller ES, Wisner KL.Looking beyond the pain: Can effective labor analgesia prevent the development of postpartum depression?In press, Anesthesia & Analgesia.

The association of serum C-Reactive Protein with the occurrence and course of postpartum depression

2018 Miller ES, Hoxha D, Pinheiro E, Grobman WA, Wisner KL.The association of serum C-Reactive Protein with the occurrence and course of postpartum depression.In press, Arch Women’s Mental Health.

Biomarkers of inflammation in perinatal depression

2018 Miller ES, Clayberger C, Sakowicz A, Roy A, Yang A, Sullivan JT, Grobman WA, Wisner KL.Biomarkers of inflammation in perinatal depression.Submitted.

Therapeutic drug monitoring in pregnancy. In Reproductive and Developmental Toxicology, 1st edition

Campbell SC, Salisbury LM, Roberts JK, Kamyar M, Fredrickson J, Costantine MM, Sherwin CMT. Therapeutic drug monitoring in pregnancy. In Reproductive and Developmental Toxicology, 1^st edition, Academic Press/Elsevier, 2017

Therapeutic roles of statins in gynecology and obstetrics: the current evidence

Zeybek B, Costantine M, Kilic G, Borahay M. Therapeutic roles of statins in gynecology and obstetrics: the current evidence. Rep Sci. 2018 in press

Inclusion of pregnant and breastfeeding women in research

Illamola SM, Bucci-Rechtweg C, Costantine MM, Tsilou K, Sherwin CM, Zajicek A. Inclusion of pregnant and breastfeeding women in research. Br J clinic Pharacol 2017. In press

The impact of exposure to antidepressant medications during pregnancy on neonatal outcomes: a review of retrospective database cohort studies

Tak CR, Job KM, Schoen-Gentry K, Campbell SC, Carroll P, Costantine M, Brixner D, Birnbaun AK, Sherwin CMT. The impact of exposure to antidepressant medications during pregnancy on neonatal outcomes: a review of retrospective database cohort studies. Eur J Clin Pharmacol 2017; 73:1055-1069.

Should we add pravastatin to aspirin for preeclampsia prevention in high-risk women?

Marrs CC, Costantine MM. Should we add pravastatin to aspirin for preeclampsia prevention in high-risk women? Clin Obstet Gynecol 2017;60:161-8.  

Pravastatin to prevent obstetrical complications in women with antiphospholipid syndrome

Costantine MM. Pravastatin to prevent obstetrical complications in women with antiphospholipid syndrome. J Clin Invest, 2016;126:2792-4.

Prednisone Pharmacokinetics During Pregnancy and Lactation

Ryu, R. J., Easterling, T. R., Caritis, S. N., Venkataramanan, R. , Umans, J. G., Ahmed, M. S., Clark, S. , Kantrowitz‐Gordon, I. , Hays, K. , Bennett, B. , Honaker, M. T., Thummel, K. E., Shen, D. D. and Hebert, M. F. (2018), Prednisone Pharmacokinetics During Pregnancy and Lactation. The Journal of Clinical Pharmacology, 58: 1223-1232. doi:10.1002/jcph.1122

Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression

Miller ES, Sakowicz A, Roy A, Yang A, Sullivan JT, Grobman WA, Wisner KL.  Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression.  Am J Obstetrics & Gynecology 220:271.e1-271.e10, 2019. PMID: 30557551

Attention to prevention-Can we stop perinatal depression before it starts?

Wisner KL, Miller ES, Tandon D.  Attention to prevention-Can we stop perinatal depression before it starts? JAMA Psychiatry 76(4):355-356. PMID: 30747943

Screening and Treatment After Implementation of a Universal Perinatal Depression Screening Program

Miller ES, Wisner KL, Gollan J, Hamade S, Gossett DR, Grobman WA.  Screening and Treatment After Implementation of a Universal Perinatal Depression Screening Program.  Obstet Gynecol 134(2):303-309, 2019.   PMID: 31306329

Risk-benefit assessment of infant exposure to lithium through breast milk: A systematic review of the literature

Newmark RL, Bogen DL, Isaac M, Wisner KL, Ciolino JD, Clark CT.  Risk-benefit assessment of infant exposure to lithium through breast milk:  A systematic review of the literature. Int Rev Psychiatry 31(3):295-304, 2019.  PMID: 31180257

Management of Women with Bipolar II Disorder during Reproductive Transitions, in Bipolar II Disorder: Recognition, Treatment, and Management

Moses-Kolko EL, Clark CT, DeBrunner S, Wisner KL.  Management of Women with Bipolar II Disorder during Reproductive Transitions, in Bipolar II Disorder: Recognition, Treatment, and Management.  Swartz HA, Suppes T, Eds, American Psychiatric Association Publishing, 2019

Research Recommendations from the National Institutes of Health Workshop on Predicting, Preventing and Treating Preeclampsia

Maric-Bilkan C, Abrahams VM, Arteaga SS, Bourjeily G, Conrad KP, Catov JM, Costantine MM, Cox B, Garovic V, George EM, Gernand AD, Jeyabalan AJ, Karumanchi SA, Laposky AD, Miodovnik M, Mitchell M, Pemberton VL, Reddy UM, Santillan M, Tsigas E, Thornburg KLR,  Ward K, Myatt L, Roberts JM Et al. Research Recommendations from the National Institutes of Health Workshop on Predicting, Preventing and Treating Preeclampsia. Hypertension 2019. In press

The First FDA-Indicated Drug for Postpartum Depression—Brexanolone

Wisner KL, Stika CS, Ciolino JD.  The First FDA-Indicated Drug for Postpartum Depression—Brexanolone. In press, JAMA Psychiatry. PMID: 31241747

Pharmacotherapy for Depression and Bipolar Disorder during Lactation: A Framework to Aid Decision Making

Sprague J, Wisner KL, Bogen DL.  Pharmacotherapy for Depression and Bipolar Disorder during Lactation: A Framework to Aid Decision Making.  In press, Seminars in Perinatology.

A common clinical conundrum: Antidepressant treatment of depression in pregnant women

Mesches GA, Wisner KL, Betcher HK.  A common clinical conundrum: Antidepressant treatment of depression in pregnant women.  In press, Seminars in Perinatology.

Psychotropic treatment during pregnancy: Research synthesis and clinical care principles

Betcher HB, Wisner KL.  Psychotropic treatment during pregnancy: Research synthesis and clinical care principles.  In press, Journal of Women’s Health.

Are adverse reproductive outcomes related to the illness or its treatment (or both)?

Wisner KL, Yonkers KA.  Are adverse reproductive outcomes related to the illness or its treatment (or both)?  In press, JAMA Psychiatry.

Pravastatin to ameliorate early onset preeclampsia: promising but not there yet.

Costantine MM. Pravastatin to ameliorate early onset preeclampsia: promising but not there yet. Br J Obstet Gynecol 2020. In press

Novel interventions for the prevention of preeclampsia

Ma’ayeh M, Rood KM, Kniss D, Costantine MM. Novel interventions for the prevention of preeclampsia. Curr Hypertens rep 2020. In press.

Protection by exclusion: Another missed opportunity to include pregnant women in research during the COVID-19 pandemic

Costantine MM, Landon M, Saade GR. Protection by exclusion: Another missed opportunity to include pregnant women in research during the COVID-19 pandemic. Obstet Gynecol 2020; 136:26-28.

Challenges in conducting clinical research studies in pregnant women

Mckiever M, Frey H, Costantine MM. Challenges in conducting clinical research studies in pregnant women. J Pharmacokinet Pharmacodyn. 2020; 47:287-293.

Pravastatin to Ameliorate Early Onset Preeclampsia: Promising but not there yet

Costantine MM. Author’s reply re: Pravastatin to Ameliorate Early Onset Preeclampsia: Promising but not there yet. BJOG 2020;127:775-776.

Novel interventions for the prevention of preeclampsia

Ma’ayeh M, Rood KM, Kniss D, Costantine MM. Novel interventions for the prevention of preeclampsia. Curr Hypertens Rep 2020;22(2):17 doi: 10.1007/s11906-020-1026-8. PubMed PMID: 32052203.

Pravastatin to ameliorate early onset preeclampsia: promising but not there yet

Costantine MM. Pravastatin to ameliorate early onset preeclampsia: promising but not there yet. Br J Obstet Gynecol 2020;127:489.

Are adverse reproductive outcomes related to the illness or its treatment (or both)?

Wisner KL, Yonkers KA.  Are adverse reproductive outcomes related to the illness or its treatment (or both)?  JAMA Psychiatry. Published online August 28, 2019. doi:https://doi.org/10.1001/jamapsychiatry.

Pharmacotherapy for depression and bipolar disorder during lactation: A framework to aid decision making

Sprague J, Wisner KL, Bogen DL.  Pharmacotherapy for depression and bipolar disorder during lactation: A framework to aid decision making.  Semin Perinatol 44(3): 2020. PMID: 32199600

A common clinical conundrum: Antidepressant treatment of depression in pregnant women

Mesches GA, Wisner KL, Betcher HK.  A common clinical conundrum: Antidepressant treatment of depression in pregnant women.  Semin Perinatol. 44(3):151229, 2020. PMID 32085857

Psychotropic treatment during pregnancy: Research synthesis and clinical care principles

Betcher HB, Wisner KL.  Psychotropic treatment during pregnancy: Research synthesis and clinical care principles.  J Women’s Health. 29(3):310-318, 2020.  PMID: 31800350

The association between antidepressant exposure and birth defects: Are we there yet?

Wisner KL, Oberlander TF, Huybrechts KF.  The association between antidepressant exposure and birth defects: Are we there yet?  JAMA Psychiatry. 2020 Aug 5. doi: 10.1001/jamapsychiatry.2020.1512. PMID: 32777006

Pregnant women are still therapeutic orphans

Wisner KL, Stika CS, Watson K.  Pregnant women are still therapeutic orphans.  World Psychiatry.  19(3):329-330, 2020  PMID: 32931103

Exclusion of pregnant women from clinical trials during the COVID-19 pandemic: A review of international registries

Smith D, Pippen J, Adesomo A, Rood K, Landon M, Costantine MM. Exclusion of pregnant women from clinical trials during the COVID-19 pandemic: A review of international registries. Am J Perinatol 2020; 37:792-799.

Prevention of preeclampsia

Maayeh M, Costantine MM. Prevention of preeclampsia. Semin Fetal Neonatal Med. 2020;25(5):101123.

The role of statins in the prevention of preeclampsia

Smith DD, Costantine MM. The role of statins in the prevention of preeclampsia. Am J Obstet Gynecol 2020. In press