Obstetric-Fetal Pharmacology Research Centers

Simultaneous quantitation of 17a-hydroxyprogesterone caproate, 17a-hydroxyprogesterone and progesterone in human plasma using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS)

Zhang, S., Mada, S. R., Sharma, S., Torch, M., Mattison, D., Caritis, S., & Venkataramanan, R. (2008). Simultaneous quantitation of 17a-hydroxyprogesterone caproate, 17a-hydroxyprogesterone and progesterone in human plasma using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS). Journal of Pharmaceutical and Biomedical Analysis, 48(4), 1174–1180. doi: 10.1016/j.jpba.2008.08.024. (PMID: 18947956)

Profiling gene expression in human placentae of different gestational ages: An OPRU Network and UW SCOR study

Mikheev, A. M., Nabekura, T., Kaddoumi, A., Bammler, T. K., Govindarajan, R., Hebert, M. F., & Unadkat, J. D. (2008). Profiling gene expression in human placentae of different gestational ages: An OPRU Network and UW SCOR study. Reproduction Science, 15(9), 866-877. doi: 10.1177/1933719108322425. (PMID: 19050320)

Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites in human and macaque plasma

Unadkat, J. D., Chung, F., Sasongko, L., Whittington, D., Eyal, S., Mankoff, D., Collier, A. C., Muzi, M., & Link, J. (2008). Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites in human and macaque plasma. Nuclear Medicine and Biology, 35(8), 911-917. doi: 10.1016/j.nucmedbio.2008.08.001. (PMID: 19026953)

Identification of enzymes involved in the metabolism of 17a-hydroxyprogesterone caproate: An effective agent for the prevention of preterm birth

Sharma, S., Ou, J., Strom, S., Mattison, D., Caritis, S., & Venkataramanan, R. (2008). Identification of enzymes involved in the metabolism of 17a-hydroxyprogesterone caproate: An effective agent for the prevention of preterm birth. Drug Metabolism and Disposition, 36(9), 1896-18902. doi: 10.1124/dmd.108.021444. (PMID: 18573861)

Transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate

Hemauer, S. J., Yan, R., Patrikeeva, S. L., Mattison, D. R., Hankins, G. D., Ahmed, M. S., & Nanovskaya, T. N. (2008). Transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate. American Journal of Obstetrics and Gynecology, 199(2), 169.e1-169.e5. doi: 10.1016/j.ajog.2007.11.065. (PMID: 18674659)

Rapid measurement of estrogens and their metabolites in human serum by liquid chromatography-tandem mass spectrometry without derivatization

Guo, T., Gu, J., Soldin, O. P., Singh, R. J., & Soldin, S. J. (2008). Rapid measurement of estrogens and their metabolites in human serum by liquid chromatography-tandem mass spectrometry without derivatization. Clinical Biochemistry, 41(9), 736-741. doi: 10.1016/j.clinbiochem.2008.02.009. (PMID: 18358240)

Serotonin syndrome associated with triptan monotherapy

Soldin, O. P., Tonning, J. M., & Obstetric-Fetal Pharmacology Research Unit Network (2008). Serotonin syndrome associated with triptan monotherapy. New England Journal of Medicine, 358(20), 2185-2186. doi: 10.1056/NEJMc0706410. (PMID: 18480219)

Metabolism of 17alpha-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons

Yan, R., Nanovskaya, T. N., Zharikova, O. L., Mattison, D. R., Hankins, G. D., & Ahmed, M. S. (2008). Metabolism of 17alpha-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons. Biochemical Pharmacology, 75(9), 1848-1857. doi: 10.1016/j.bcp.2008.01.013. (PMID: 18329004)

Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy

Dickmann, L. J., Tay, S., Senn, T. D., Zhang, H., Visone, A., Unadkat, J. D., Hebert, M. F., & Isoherranen, N. (2008). Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Biochemical Pharmacology, 75(8), 1677-1687. doi: 10.1016/j.bcp.2008.01.012. (PMID: 18342837)

Glyburide metabolism by placentas of healthy and gestational diabetics

Jain, S., Zharikova, O. L., Ravindran, S., Nanovskya, T. N., Mattison, D. R., Hankins, G. D., & Ahmed, M. S. (2008). Glyburide metabolism by placentas of healthy and gestational diabetics. American Journal of Perinatology, 25(3), 169-174. doi: 10.1055/s-2008-1061503. (PMID: 18300189)

Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide

Nanovskaya, T. N., Patrikeeva, S., Hemauer, S., Fokina, V., Mattison, D., Hankins, G. D., Ahmed, M. S., & OPRU Network (2008). Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide. Journal of Maternal Fetal & Neonatal Medicine, 21(3), 197-207. doi: 10.1080/14767050801929901. (PMID: 18297575)

The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: An Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study

Zhou, L., Naraharisetti, S. B., Wang, H., Unadkat, J. D., Hebert, M. F., & Mao, Q. (2008). The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: An Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study. Molecular Pharmacology, 73(3), 949–959. doi: 10.1124/mol.107.041616. (PMID: 18079276)

Triptans in pregnancy

Soldin, O. P., Dahlin, J., & O'Mara, D. M. (2008). Triptans in pregnancy. Therapeutic Drug Monitoring, 30(1), 5-9. doi: 10.1097/FTD.0b013e318162c89b. (PMID: 18223456)

The effect of esterases on 17alpha-hydroxyprogesterone caproate

Yan, R., Fokina, V., Hankins, G. D., Ahmed, M. S., & Nanovskaya, T. N. (2008). The effect of esterases on 17alpha-hydroxyprogesterone caproate. American Journal of Obstetrics and Gynecology, 198(2), 229.e1-229.e5. doi: DOI: 10.1016/j.ajog.2007.07.038. (PMID: 17936237)

Human decidual cell Toll-like receptor signaling in response to endotoxin: The effect of progestins

Simhan, H. N., Chiao, J. P., Mattison, D. R., & Caritis, S. N. (2008). Human decidual cell Toll-like receptor signaling in response to endotoxin: The effect of progestins. American Journal of Obstetrics and Gynecology, 198(1), 119.e1-119.e4. doi: 10.1016/j.ajog.2007.06.022. (PMID: 17936235)

Physiologically based pharmacokinetic model of midazolam disposition during pregnancy

Andrew, M. A., Hebert, M. F., Vicini, P. (2008). Physiologically based pharmacokinetic model of midazolam disposition during pregnancy. Conference Proceedings: IEEE Engineering in Medicine and Biology Society, 2008, 5454-5457. doi: 10.1109/IEMBS.2008.4650448. (PMID: 19163951)