2024

• Kolasangiani R., Farzanian K., Chen Y., Schwartz M. A., Bidone T. C., Conformational response of αIIbβ3 and αVβ3 integrins to force. Structure, 2024. doi: 10.1016/j.str.2024.11.016.
• Din M., Paul S., Ullah S., Yang H., Xu R., Abidin N. A. Z., Sun A., Chen Y. C., Gao R., Chowdhury B., Zhou F., Rogers S., Miller M., Biswas A., Hu L., Fan Z., Zahner C., Fan J., Chen Z., Berman M., Xue L., Ju L. A., Chen Y.*, Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging. Nature Communications, 2024, 15, 9067. doi: 10.1038/s41467-024-53069-9.  (*Correspondence).
• Pulikkot S., Paul S., Hall A., Gardner B., Liu W., Hu L., Vella A. T., Chen Y.*, Fan Z., Monitoring circulating myeloid cells in peritonitis with in vivo imaging flow cytometer. Biomolecules. 2024 14(8), 886. doi: 10.3390/biom14080886. (*Co-correspondence)
• Chen Y, Li Z, Kong F, Ju LA, Zhu C. Force-Regulated Spontaneous Conformational Changes of Integrins α5β1 and αVβ3. ACS Nano. 2024 Jan 9;18(1):299-313. doi: 10.1021/acsnano.3c06253.
• Gagnon MG, Ling J. Editorial: tRNA and protein synthesis in microorganisms. Front Microbiol. 2024 Oct 30;15:1509450. doi: 10.3389/fmicb.2024.1509450.
• Li L, Rybak MY, Lin J, Gagnon MG. The ribosome termination complex remodels release factor RF3 and ejects GDP. Nat Struct Mol Biol. 2024 Dec;31(12):1909-1920. doi: 10.1038/s41594-024-01360-0.
• Rybak MY, Gagnon MG. Structures of the ribosome bound to EF-Tu-isoleucine tRNA elucidate the mechanism of AUG avoidance. Nat Struct Mol Biol. 2024 May;31(5):810-816. doi: 10.1038/s41594-024-01236-3.
• Seely SM, Basu RS, Gagnon MG. Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res. 2024 Apr 24;52(7):4053-4066. doi: 10.1093/nar/gkae128.
• Helena-Bueno K, Rybak MY, Ekemezie CL, Sullivan R, Brown CR, Dingwall C, Baslé A, Schneider C, Connolly JPR, Blaza JN, Csörgő B, Moynihan PJ, Gagnon MG, Hill CH, Melnikov SV. A new family of bacterial ribosome hibernation factors. Nature. 2024 Feb;626(8001):1125-1132. doi: 10.1038/s41586-024-07041-8.
• Iwahara J, Williams DC Jr. Editorial overview: New perspectives on the structure and dynamics of protein-nucleic acid interactions. Curr Opin Struct Biol. 2025 Feb;90:102957. doi: 10.1016/j.sbi.2024.102957.
• Yu B, Bolik-Coulon N, Rangadurai AK, Kay LE, Iwahara J. Gadolinium-Based NMR Spin Relaxation Measurements of Near-Surface Electrostatic Potentials of Biomolecules. J Am Chem Soc. 2024 Jul 31;146(30):20788-20801. doi: 10.1021/jacs.4c04433.
• Wang X, Holthauzen LMF, Paz-Villatoro JM, Bien KG, Yu B, Iwahara J. Phosphorylation by Protein Kinase C Weakens DNA-Binding Affinity and Folding Stability of the HMGB1 Protein. Biochemistry. 2024 Jul 16;63(14):1718-1722. doi: 10.1021/acs.biochem.4c00194.
• Yu B, Wang X, Tan KN, Iwahara J. Influence of an Intrinsically Disordered Region on Protein Domains Revealed by NMR-Based Electrostatic Potential Measurements. J Am Chem Soc. 2024 Jun 5;146(22):14922-14926. doi: 10.1021/jacs.4c03254.
• Iwahara J. Transient helices with functional roles. Biophys J. 2024 Feb 2:S0006-3495(24)00096-1. doi: 10.1016/j.bpj.2024.01.038.
• Wang X, Yu B, Sakurabayashi S, Paz-Villatoro JM, Iwahara J. Robust Enzymatic Production of DNA G-Quadruplex, Aptamer, DNAzyme, and Other Oligonucleotides: Applications for NMR. J Am Chem Soc. 2024 Jan 24;146(3):1748-1752. doi: 10.1021/jacs.3c11219.
• Gerken H, Shetty D, Kern B, Kenney LJ, Misra R. Effects of pleiotropic ompR and envZ alleles of Escherichia coli on envelope stress and antibiotic sensitivity. J Bacteriol. 2024 Jun 20;206(6):e0017224. doi: 10.1128/jb.00172-24.
• Kenney LJ. Peeling the onion: additional layers of regulation in the acid stress response. J Bacteriol. 2024 Apr 18;206(4):e0006924. doi: 10.1128/jb.00069-24.
• Singh MK, Kenney LJ. Visualizing the invisible: novel approaches to visualizing bacterial proteins and host-pathogen interactions. Front Bioeng Biotechnol. 2024 Feb 13;12:1334503. doi: 10.3389/fbioe.
• Kielkopf CS, Shneider MM, Leiman PG, Taylor NMI. T6SS-associated Rhs toxin-encapsulating shells: Structural and bioinformatical insights into bacterial weaponry and self-protection. Structure. 2024 Dec 5;32(12):2375-2389.e5. doi: 10.1016/j.str.2024.10.008.
• Sonani RR, Palmer LK, Esteves NC, Horton AA, Sebastian AL, Kelly RJ, Wang F, Kreutzberger MAB, Russell WK, Leiman PG, Scharf BE, Egelman EH. An extensive disulfide bond network prevents tail contraction in Agrobacterium tumefaciens phage Milano. Nat Commun. 2024 Jan 26;15(1):756. doi: 10.1038/s41467-024-44959-z.
• Matheny CJ, Qadota H, Bailey AO, Valdebenito-Silva S, Oberhauser AF, Benian GM. The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging. Mol Biol Cell. 2024 Jul 1;35(7):ar98. doi: 10.1091/mbc.E23-12-0488.
• Workman RJ, Huang CJ, Lynch GC, Pettitt BM. Peptide diffusion in biomolecular condensates. Biophys J. 2024 Jun 18;123(12):1668-1675. doi: 10.1016/j.bpj.2024.05.009.
• Lowry E, Chellappa RC, Penaranda B, Sawant KV, Wakamiya M, Garofalo RP, Rajarathnam K. Cxcl17 is a proinflammatory chemokine and promotes neutrophil trafficking. J Leukoc Biol. 2024 Jan 31:qiae028. doi: 10.1093/jleuko/qiae028.
• León-Vega II, Vadillo E, Vargas-Robles H, Rajarathnam K, Schnoor M. Cxcl1 monomer-dimer equilibrium controls neutrophil extravasation. J Leukoc Biol. 2024 Feb 23;115(3):565-572. doi: 10.1093/jleuko/qiad159.
• Lazennec G, Rajarathnam K, Richmond A. CXCR2 chemokine receptor - a master regulator in cancer and physiology. Trends Mol Med. 2024 Jan;30(1):37-55. doi: 10.1016/j.molmed.2023.09.003.
• Fan S, Liu J, Chofflet N, Bailey AO, Russell WK, Zhang Z, Takahashi H, Ren G, Rudenko G. Molecular mechanism of contactin 2 homophilic interaction. Structure. 2024 Oct 3;32(10):1652-1666.e8. doi: 10.1016/j.str.2024.06.004.
• Chofflet N, Naito Y, Pastore AJ, Padmanabhan N, Nguyen PT, Poitras C, Feller B, Yi N, Van Prooijen J, Khaled H, Coulombe B, Clapcote SJ, Bourgault S, Siddiqui TJ, Rudenko G, Takahashi H. Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization. Front Mol Neurosci. 2024 Mar 20;17:1371145. doi: 10.3389/fnmol.2024.1371145.
• Lin SZ, Changede R, Farrugia AJ, Bershadsky AD, Sheetz MP, Prost J, Rupprecht JF. Membrane Tilt Drives Phase Separation of Adhesion Receptors. Phys Rev Lett. 2024 May 3;132(18):188402. doi: 10.1103/PhysRevLett.132.188402.
• Jain K, Minhaj RF, Kanchanawong P, Sheetz MP, Changede R. Nano-clusters of ligand-activated integrins organize immobile, signalling active, nano-clusters of phosphorylated FAK required for mechanosignaling in focal adhesions. bioRxiv [Preprint]. 2024 Feb 27:2024.02.25.581925. doi: 10.1101/2024.02.25.581925.
• Jain K, Pandey A, Wang H, Chung T, Nemati A, Kanchanawong P, Sheetz MP, Cai H, Changede R. TiO2 Nano-Biopatterning Reveals Optimal Ligand Presentation for Cell-Matrix Adhesion Formation. Adv Mater. 2024 Feb 10:e2309284. doi: 10.1002/adma.202309284.
• Kureel SK, Blair B, Sheetz MP. Recent Advancement in Elimination Strategies and Potential Rejuvenation Targets of Senescence. Adv Biol (Weinh). 2024 Jan;8(1):e2300461. doi: 10.1002/adbi.202300461.
• Refaat M, ElRakaiby MT, El Hariri El Nokab M, Es Sayed J, Elshewy A, Sebakhy KO, Moneib N, Wang T, Smith TJ, Habib MH. Polymerization potential of a bacterial CotA-laccase for β-naphthol: enzyme structure and comprehensive polymer characterization. Front Microbiol. 2024 Nov 21;15:1501112. doi: 10.3389/fmicb.2024.1501112.
• Sherman M, Cox F, Smith H, Habib MH, Karst S, Wobus CE, Smith TJ. The reversible activation of norovirus by metal ions. J Virol. 2024 Feb 20;98(2):e0173523. doi: 10.1128/jvi.01735-23.
• Babula JJ, Bui D, Stevenson HL, Watowich SJ, Neelakantan H. Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction. Diabetes Obes Metab. 2024 Nov;26(11):5272-5282. doi: 10.1111/dom.15879.
• Dimet-Wiley AL, Latham CM, Brightwell CR, Neelakantan H, Keeble AR, Thomas NT, Noehren H, Fry CS, Watowich SJ. Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep. 2024 Jul 5;14(1):15554. doi: 10.1038/s41598-024-66034-9.
• Shinde DP, Plante JA, Scharton D, Mitchell B, Walker J, Azar SR, Campos RK, Sacchetto L, Drumond BP, Vasilakis N, Plante KS, Weaver SC. Potential role of heterologous flavivirus immunity in preventing urban transmission of yellow fever virus. Nat Commun. 2024 Nov 10;15(1):9728. doi: 10.1038/s41467-024-54146-9.
• Shinde DP, Walker J, Reyna RA, Scharton D, Mitchell B, Dulaney E, Bonam SR, Hu H, Plante JA, Plante KS, Weaver SC. Mechanisms of Flavivirus Cross-Protection against Yellow Fever in a Mouse Model. Viruses. 2024 May 24;16(6):836. doi: 10.3390/v16060836.
• Le Duc JW, Weaver SC. A Bottom-Up Approach to Biosecurity. Health Secur. 2024 Aug;22(4):343-346. doi: 10.1089/hs.2023.0170.
• de Souza WM, Weaver SC. Effects of climate change and human activities on vector-borne diseases. Nat Rev Microbiol. 2024 Aug;22(8):476-491. doi: 10.1038/s41579-024-01026-0.
• Jacob-Nascimento LC, Portilho MM, Anjos RO, Moreira PSS, Stauber C, Weaver SC, Kitron U, Reis MG, Ribeiro GS. Detection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis? Viruses. 2024 Feb 2;16(2):235. doi: 10.3390/v16020235.
• de Souza WM, Ribeiro GS, de Lima STS, de Jesus R, Moreira FRR, Whittaker C, Sallum MAM, Carrington CVF, Sabino EC, Kitron U, Faria NR, Weaver SC. Chikungunya: a decade of burden in the Americas. Lancet Reg Health Am. 2024 Jan 8;30:100673. doi: 10.1016/j.lana.2023.100673.
• Park J, Herrmann GK, Roy A, Shumate CK, Cisneros GA, Yin YW. An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol γ. Sci Adv. 2024 May 24;10(21):eadl3214. doi: 10.1126/sciadv.adl3214.
• Khakhum N, Baruch-Torres N, Stockton JL, Chapartegui-González I, Badten AJ, Adam A, Wang T, Huerta-Saquero A, Yin YW, Torres AG. Decoration of Burkholderia Hcp1 protein to virus-like particles as a vaccine delivery platform. Infect Immun. 2024 Feb 14:e0001924. doi: 10.1128/iai.00019-24.