The REHAB-HFpEF trial is testing whether a new physical rehabilitation program can help people who were hospitalized for heart failure with preserved ejection fraction (HFpEF). HFpEF is a condition mostly affecting older adults, and there are limited treatment options available. The main goal of the study is to see if this program can reduce hospital readmissions and deaths, and improve mobility over a 6-month period.

The REHAB-HFpEF trial is a large study involving 880 patients aged 60 and older, who were hospitalized for heart failure with preserved ejection fraction (HFpEF). The trial will test whether a special, personalized physical rehabilitation program can help these patients live better. The program includes exercises aimed at improving strength, balance, endurance, and mobility, and will start while the patients are still in the hospital. They’ll continue the program for 12 weeks after they leave the hospital, with exercises three times a week in an outpatient setting. 

Researchers will track whether the program helps reduce the chances of being readmitted to the hospital or dying within 6 months, which is the main goal. They’ll also look at whether it helps improve mobility and reduce major disability.

Participants will be randomly assigned to either the rehabilitation program or a control group. Those in the control group won’t receive specific exercise recommendations but will stay in touch with study staff for regular updates on their health. Everyone will continue to receive the usual care prescribed by their doctors.

This study builds on earlier research that suggests this kind of rehabilitation could be very helpful for older adults with heart failure and preserved ejection fraction, a group with limited treatment options.