Mukund S. Prathivadibhayankaram, PhD

My primary research interest is understanding the pathogenesis of alcohol induced pancreatitis. My current focus as a postdoctoral researcher at the University of Texas Medical Branch (UTMB) is on the elucidation of metabolic basis for alcoholic chronic pancreatitis. My project aims in understanding the molecular mechanism and metabolic basis to identify specific therapeutic targets for alcoholic chronic pancreatitis using deer mouse model, and in vitro techniques.

Present	Postdoctoral Fellow, Department of Pathology, the University of Texas Medical Branch, Galveston, Texas
2016-2018	Postdoctoral Fellow, Center for Pharmacy and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, Georgia
2012-2016	Doctor of Philosophy (PhD) – Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India
2008-2011	Master of Science (MSc) – Medical Biochemistry, Kasturba Medical College, Manipal University, Manipal, Karnataka, India

Awards/Honors/Grants

Received Robert L Harrsion award for best poster presentation at Department of Pathology, University of Texas Medical Branch Galveston for the year 2019 on Pathology 25th Annual Trainee research day.
Received “Dr. TMA-Pai Gold medal for excellence in research” for the year 2018. Manipal University, Mangalore.
Received “Kundapur Mohan and Lata Bhandarkar’s merit-cum-means scholarship for PhD candidates” for the year 2014-15. Manipal University, Manipal.
First Prize for poster presentation at Manipal Cardiology Update 2015, Kasturba Medical College, Manipal. November 2015.
Second prize for oral presentation in International Conference on Recent discoveries of diabetic biomarkers and challenges ahead (ICDB-2015). B.S. Abdur Rahman University, Chennai. March 2015.
First Prize for poster presentation in Student’s Research Day in Kasturba Medical College, Mangalore. February 2015.
Second Prize for developing a novel prototype on “ECG Vest” to improve Emergency medical care on Innovation Day at Innovation Centre, Manipal Institute of Technology, Manipal. December 2014.
First Prize for poster presentation at International Non Communicable Diseases (NCD) Research Meet. Kasturba Medical College, Manipal. January 2014.
Consolation Cash prize for presenting innovative proposal on Audiological analysis of the acoustic patterns of cough on Innovation Day at Innovation Centre, Manipal Institute of Technology, Manipal. December 2013.
Third prize for oral presentation at International Conference on “Updates in Research Ethics and Research Methodology” Sri Ramachandra University, Chennai. March 2013.

Grants

Received Young investigator award for 50th American Pancreatic Association annual meeting. November 2019. Maui, Hawaii, USA.
Received Travel Grant for 14th World Congress on Insulin resistance Diabetes and Cardiovascular Diseases (WCIR). December 2016. Los Angeles, CA, USA.

Research Society on Alcoholism
International Society for Biomedical Research on Alcoholism

First author publications

Mukund P. Srinivasan, Kamlesh K. Bhopale, Samir M. Amer, Jie Wan, Lata Kaphalia2, Ghulam S. Ansari1, Bhupendra S. Kaphalia. Linking Dysregulated AMPK signaling and ER stress in Ethanol-induced Liver injury in Hepatic Alcohol dehydrogenase deficient deer mice. Biomolecules. 2019 Oct 2;9(10).
Mukund P. Srinivasan, Noha M. Shawky, Bhupendra S Kaphalia, Muthusamy Thangaraju, Lakshman Segar. Alcohol-induced ketonemia is associated with lowering of blood glucose, down-regulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice. Biochem Pharmacol. 2019 Feb; 160:46-61.
Mukund P Srinivasan, Padmanabh K Kamath, Narayan M Bhat, Narasimha D Pai, Chakrapani Mahabala. Basal hyperinsulinemia beyond a threshold predicts major adverse cardiac events at 1 year after coronary angiogram in type 2 diabetes mellitus: a retrospective cohort study. Diabetol Metab Syndr. 2017; 9:38.
Mukund P Srinivasan, Padmanabh K Kamath, Narayan M Bhat, Narasimha D Pai, Chakrapani Mahabala. Risk factors for Complex and Severe Coronary Artery Disease in Type 2 Diabetes Mellitus. J Cardiovasc Disease Res. 2017; 8(1): 19-23.
Srinivasan MP, Kamath PK, Bhat NM, Pai ND, Bhat RU, Manjrekar PA, Mahabala C. The Manipal Diabetes Coronary Artery Severity Score. Diabetes Metab Syndr. 2016 Aug 22.
Mukund P Srinivasan, Padmanabh K Kamath, Narasimha D Pai, Rajesh U Bhat, Narayan M Bhat, Tejas D Shah, Anish Singhal, Chakrapani Mahabala. Severity of Coronary Artery Disease in type 2 Diabetes Mellitus: Does the timing matter? Indian Heart J. 2016; 68(2):158-63.
Srinivasan MP, Kamath PK, Bhat MN, Pai ND, Manjrekar PA, Mahabala C. Factors associated with no apparent coronary artery disease in patients with type 2 diabetes mellitus for more than 10 years of duration: a case control study. Cardiovasc Diabetol. 2015 Oct 31; 14 (1):146.
Srinivasan MP, Kamath PK, Pai ND, Manjrekar PA, Mahabala C. Factors Correlating with Severity of Coronary Artery Disease in Type 2 Diabetic Patients on Treatment for More Than 5 Years. BJMMR. 2014; 4:4364–72.
Srinivasan MP, Kamath PK, Manjrekar PA, Unnikrishnan B, Ullal A, Kotekar MF, et al. Correlation of severity of coronary artery disease with insulin resistance. North Am J Med Sci. 2013; 5: 611-4. (a) Highlighted in: Kannan L, Chernoff A. Insulin resistance and atherosclerosis: Is it time to measure homa-ir to predict coronary artery disease?. North Am J Med Sci 2013; 5:615-6.

Co-author publications

Lata Kaphalia, Mukund P. Srinivasan, Ramu D. Kakumanu, Bhupendra S. Kaphalia, William J. Calhoun. Ethanol exposure impairs AMPK signaling and phagocytosis in human alveolar macrophages: Role of ethanol metabolism. Alcohol Clin Exp Res. 2019 Aug; 43(8):1682-1694.
Lata Kaphalia, Mukund P. Srinivasan, Bhupendra S. Kaphalia, William J. Calhoun. Over Expression of Cathepsin B and its induction by Ethanol in Asthmatic Vs Non-Asthmatic Bronchial Epithelial Cells and related AMPKα and ER Stress Signaling. Am J Respir Crit Care Med 2019; 199:A3814.
Gutta S, Shenoy J, Kamath SP, Mithra P, Baliga BS, Sarpangala M, Srinivasan M. Light Emitting Diode (LED) Phototherapy versus Conventional Phototherapy in Neonatal Hyperbilirubinemia: A Single Blinded Randomized Control Trial from Coastal India. Biomed Res Int. 2019 Apr 11; 2019:6274719.
Rohit Shenoy, Rajesh Bhat, Mukund Srinivasan, Chakrapani Mahabala, Unnikrishnan Bhaskaran. Correlation between Insulin Resistance and Severity of Coronary Artery Disease in Non-Diabetes. Asian J Pharm Clin Res. Vol 9; Issue 6, 2016, 331-333.
Singhal A, Pai S, Kamath P, Kini R, S MP, Mahabala C. Syntax score - A predictor of coronary collateral status. Natl J Physiol Pharm Pharmacol.04 Mar, 2016.
Rajesh Bhat Uppoor, Aparna Rajesh, Mukund Prathathivadibhayankaram Srinivasan, Bhaskaran Unnikrishnan, Ramesh Holla. Oxidative Stress in Obese Postmenopausal Women: An Additive Burden for Atherosclerosis. J Clin Diagn Res. 2015 Dec 15; 9 (12): OC03- OC05.
Virupaksha D, Panambur VB, Harini R, Ann TT, Amrita R, Harisha K, Mukund P Srinivasan, Chethan AJ, Safiulla BS, Puneeth HS, M Prakash, Veena N .A Comparative Study Between Yakshagana Artists and Healthy Controls for Antioxidant Markers and Liver Function Parameters. International journal of health sciences and Research. Vol 2; Issue 1; April 2012.

Conference Presentations

Symposium on “RECENT ADVANCES IN UNDERSTANDING THE COMPLEXITY OF ALCOHOL-INDUCED PANCREATIC DYSFUNCTION AND PANCREATITIS DEVELOPMENT” Research Society of Alcoholism 42nd annual scientific meeting held on June 22 – 26, 2019 at Minneapolis, Minnesota [Invited Talk].
Mukund Srinivasan, Noha Shawky, Muthusamy Thangaraju, Lakshman Segar. Alcohol induced ketonemia and euglycemia are associated with suppression of hepatic gluconeogeneisis and glycogenesis in type 2 diabetic db/db mice. 8th Annual Southern Translation Education and Research STaR Conference. September 2017. Augutsa, GA, USA. [Poster].
Mukund Srinivasan, Padmanabh Kamath, Narayan Bhat, Narasimha Pai, Poornima Manjrekar, Chakrapani Mahabala. Basal hyperinsulinemia beyond a threshold predicts adverse cardiac events at one year after Coronary Angiogram in type 2 diabetes mellitus. 14th World Congress on Insulin resistance Diabetes and Cardiovascular Diseases (WCIR). December 2016. Los Angeles, CA, USA. [Talk].
Mukund Srinivasan, Padmanabh Kamath, Narayan Bhat, Narasimha Pai, Poornima Manjrekar, Chakrapani Mahabala. Insulin resistance as a predictor of adverse cardiac events. Manipal Cardiology update-2015, Kasturba Medical College, Manipal. November 2015. [Poster]
.Mukund Srinivasan, Padmanabh Kamath, Narayan Bhat, Narasimha Pai, Poornima Manjrekar, Chakrapani Mahabala. Risk factors for Complex and Severe Coronary Artery Disease in Type 2 Diabetes Mellitus: Hyperinsulinemia as a marker for severe and complex coronary artery disease. International Cardio Diabetes Conference (ICDC 2015). Mangalore October 2015. [Talk]
Mukund P S, Padmanabh Kamath, Poornima Manjrekar, Chakrapani Mahabala. Insulin resistance as a marker of severe coronary artery disease in type 2 diabetes mellitus: The Neglected Villain. International Conference on Recent discoveries of diabetic biomarkers and challenges ahead (ICDB-2015). Chennai. March 2015. [Talk].
MP Srinivasan, C Mahabala, RL Kamath, MN Bhat, ND Pai, RU Bhat, PK Kamath. Factors associated with Normal Coronary Arteries in patients with Type 2 Diabetes Mellitus for more than 10 years of duration. 66th Cardiological Society of India. Hyderabad. December 2014. [Talk].
Mukund Srinivasan, Padmanabh Kamath2, Narayan Bhat, Narasimha Pai, Poornima Manjrekar, Chakrapani Mahabala. Manipal Diabetes Coronary Artery Severity Score. 32nd World Congress of Internal Medicine. Seoul, South Korea. October 2014. [Poster].
Mukund P S, Padmanabh Kamath, Narasimha Pai, Poornima Manjrekar, Chakrapani M. Insulin Resistance in Diabetic Coronary Artery Disease with more than 5 years of Type 2 Diabetes Mellitus: An Unseen Villain. International Non Communicable Diseases (NCD) Research Meet. Kasturba Medical College, Manipal. 2014. [Poster].
Mukund P S, Padmanabha Kamath, Poornima Manjrekar, Chakrapani M. Correlation of risk factors with Angiographic severity of Ischemic Heart Disease with special reference to Insulin Resistance. International Conference on “Updates in Research Ethics and Research Methodology” Sri Ramachandra University, Chennai. 4th and 5th March 2013. [Talk].

Pathology Post Doctoral Program Directory