Year in Program: GS2
Mentor: Dr. Lawrence Sowers
Graduate Program: Pharmacology/Toxicology
Research Interests:
I am interested in the metabolic pathways that contribute to chemotherapy resistance in glioblastoma as well as processes involved in DNA repair. Previously at UT Austin, I investigated how binding motifs impact the specificity and efficiency of human helicase-mediated disruption of secondary DNA/RNA structures.
Honors & Awards:
- Translational Science Training Grant (TL1) from NCATS, UTMB (2024- )
- Truman G. Blocker Endowment for the MD/PhD Program (2022-2023)
- John Sealy School of Medicine Research Scholarship Grant (2022)
- UT Austin Graduate with Honors and Research Distinction (2020)
- UT Austin Undergraduate Research Fellowship (2018)
Research Activities:
Researchgate:
Baljinnyam, T., Conrad, J. W., Sowers, M. L., Chang-Gu, B., Herring, J. L., Hackfeld, L. C., ... & Sowers, L. C. (2023). Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing. Chemical Research in Toxicology, 36(2), 162-176.
Sowers, M. L., Conrad, J. W., Chang-Gu, B., Cherryhomes, E., Hackfeld, L. C., & Sowers, L. C. (2023). DNA Base Excision Repair Intermediates Influence Duplex–Quadruplex Equilibrium. Molecules, 28(3), 970.
Chang-Gu, B., Venkatesan, S., & Russell, R. (2022). Kinetics measurements of G-quadruplex binding and unfolding by helicases. Methods.
Chang-Gu, B., Bradburn, D., Yangyuoru, P. M., & Russell, R. (2021). The DHX36-specific-motif (DSM) enhances specificity by accelerating recruitment of DNA G-quadruplex structures. Biological Chemistry, 402(5), 593-604.