Dancing Molecules Might Restore Your Dancing

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Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury
The signaling of cells by scaffolds of synthetic molecules that mimic proteins is known to be effective in the regeneration of tissues. Here, we describe peptide amphiphile supramolecular polymers containing two distinct signals and test them in a mouse model of severe spinal cord injury...

Fixing Spinal Cord Injuries With 'Dancing Molecules'
In a new injectable therapy that repairs spinal cord injuries, molecules form nanofibers that 'dance' around, making communication with cells to repair the injured spinal cord more likely...

A dynamic duo: Self-assembly of nanofibers facilitates the repair of spinal cord injury in mice
The extracellular matrix (ECM) is a vital component of all tissues that contributes to the physical and chemical cues that can affect cell fate. The design of materials to encourage the repair of tissue after injury is a long-standing goal of regenerative medicine. Supramolecular polymers based on reversible noncovalent interactions form fibrous materials that can act as simple but tailored ECM mimics. On page 848 of this issue, Álvarez et al. (1) show that tuning the dynamics of bioactive supramolecular polymers correlates with the degree of regeneration and functional outcome after acute spinal cord injury (SCI) in mice...