| Syphilis IgG Screen (088-0236) | |
|---|---|
| Test Mnemonic: | SYPG |
| Specimen Requirements: | |
| Test Included: | Syphilis IgG EIA. If positive, reflex to RPR titer and TP-PA confirmation tests |
| Collection: | SST (Serum separator tube) |
| Container: | SST |
| Minimum Volume: | 1 ml of serum |
| Storage/Transport: | Refrigerated. |
| Specimen Preparation: | Within two hours of collection, centrifuge |
| Stability: | 7 days, refrigerated; indefinitely frozen |
| Causes for Rejection: | Insufficient quantity, gross hemolysis, lipemia Specimen container unlabeled or labeled incorrectly. No date and time of collection or collector completed. |
| Reference Range: | Negative or Non-reactive |
| Turnaround Time: | Test is performed daily, Monday through Friday |
| Methodology: | Multiplex immunoassay, RPR, TP-PA |
| Performed: | Clinical Microbiology |
| Synonyms: | RPR, Rapid Plasma Reagin; Syphilis; Tertiary Syphilis; VDRL |
| Clinical Indication: | Infection with Treponema pallidium, primary, secondary, latent or tertiary syphilis stages. Treponemal IgG test does not distinguish between recent or past infection, nor is it used to assess response to treatment. |
| Patient Preparation : | Routine venipuncture |
| CPT 4 Code: | 86780, 86753: RPR |
| Note: | Specimens with positive syphilis IgG results are automatically tested for RPR titer and a confirmatory treponemal test (Treponema pallidum partical agglutination test). For patients diagnosed with syphilis (i.e., positive IgG and confirmatory test), the CDC recommends that response to therapy be assessed by RPR test (a 4-fold decline in titer, or undetectable RPR titer) after 6 months. Exception: Specimens from Labor and Delivery are tested if seven days have elapsed since the last test. Tests are performed on all obstetrics patients regardless of previous results. If there is no previous patient data, the requested tests are performed. VDRL test is performed on CSF samples as a Sendout test for patients with positive serum test results, only. |
| When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent. | |