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Anti-Centromere B Antibody (8000100453)
Test Mnemonic:
Specimen Requirements:
Collection:

SST ( serum separator tube) - yellow top

Container:

SST

Minimum Volume:

1mL of serum

Storage/Transport:

Room temperature. Refrigerate 2-8'C if delay in transport

Specimen Preparation:

Within 2 hours of collection, centrifuge

Stability:

7 days refrigerated; indefinitely frozen

Causes for Rejection:

Improper collection, gross hemolysis.  Specimen container unlabeled or labeled incorrectly. No date and time of collection on requisition form.

Reference Range:
Centromere antibody is present in 80-90% of individuals with CREST variant scleroderma. This antibody is also seen in 30% of Raynaud patients, 12% of patients with mixed connective-tissue disease, diffuse scleroderma, interstitial pulmonary fibrosis, primary biliary cirrhosis, and in a smaller percent of patients with systemic lupus erythematosus (SLE) and RA.   
Turnaround Time:

 Test is performed daily, Monday through Friday

Methodology:

Multiplexing bead immunoassay

Performed:

Clinical Microbiology

Synonyms:

Centromere Antibody; ENA Antibodies; Anti-Centromere Antibody

Clinical Indication:

Autoimmune disease screening

 

Patient Preparation :

Routine venipuncture

CPT 4 Code:

83516

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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